4765-59-7

4765-59-7 structure

Name: 2-(4-Nitrophenyl)Quinazolin-4(1H)-One
Chemical Name: 2-(4-nitrophenyl)-1H-quinazolin-4-one
CAS Number: 4765-59-7
Molecular Formula: C₁₄H₉N₃O₃
Molecular Weight: 267.24
Catalog: Signaling Pathways Cell Cycle/DNA Damage PARP
Create Date: 2016-04-12 17:24:24
Modify Date: 2024-01-02 07:25:59
TNKS-2-IN-1 (Compound 13g) is a TNKS-2 inhibitor. TNKS-2-IN-1 inhibits TNKS-1 and TNKS-2 with IC50s of 259 nM and 1100 nM[1].

Name	2-(4-nitrophenyl)-1H-quinazolin-4-one
Synonyms	2-<4-Nitro-phenyl>-4-oxo-chinazolin

Description	TNKS-2-IN-1 (Compound 13g) is a TNKS-2 inhibitor. TNKS-2-IN-1 inhibits TNKS-1 and TNKS-2 with IC50s of 259 nM and 1100 nM[1].
Related Catalog	Signaling Pathways >> Epigenetics >> PARP Research Areas >> Others Signaling Pathways >> Cell Cycle/DNA Damage >> PARP
References	[1]. Nathubhai A, et al. Structure-activity relationships of 2-arylquinazolin-4-ones as highly selective and potent inhibitors of the tankyrases. Eur J Med Chem. 2016 Aug 8;118:316-27.