2-(4-Nitrophenyl)Quinazolin-4(1H)-One

Modify Date: 2025-09-12 12:50:22

2-(4-Nitrophenyl)Quinazolin-4(1H)-One structure	Common Name	2-(4-Nitrophenyl)Quinazolin-4(1H)-One
	CAS Number	4765-59-7	Molecular Weight	267.24
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₄H₉N₃O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 2-(4-Nitrophenyl)Quinazolin-4(1H)-One

TNKS-2-IN-1 (Compound 13g) is a TNKS-2 inhibitor. TNKS-2-IN-1 inhibits TNKS-1 and TNKS-2 with IC50s of 259 nM and 1100 nM[1].

Name	2-(4-nitrophenyl)-1H-quinazolin-4-one
Synonym	More Synonyms

Description	TNKS-2-IN-1 (Compound 13g) is a TNKS-2 inhibitor. TNKS-2-IN-1 inhibits TNKS-1 and TNKS-2 with IC50s of 259 nM and 1100 nM[1].
Related Catalog	Signaling Pathways >> Epigenetics >> PARP Research Areas >> Others Signaling Pathways >> Cell Cycle/DNA Damage >> PARP
References	[1]. Nathubhai A, et al. Structure-activity relationships of 2-arylquinazolin-4-ones as highly selective and potent inhibitors of the tankyrases. Eur J Med Chem. 2016 Aug 8;118:316-27.

Molecular Formula	C₁₄H₉N₃O₃
Molecular Weight	267.24
Exact Mass	267.06400
PSA	91.57000
LogP	3.02150
InChIKey	PDSXUXCWTDUVSZ-UHFFFAOYSA-N
SMILES	O=c1[nH]c(-c2ccc([N+](=O)[O-])cc2)nc2ccccc12

Name: Inhibition of recombinant human CYP1A1 expressed in yeast cells at 10 uM using 7-etho...
Source: ChEMBL
Target: Cytochrome P450 1A1
External Id: CHEMBL4014744

Name: Inhibition of recombinant human CYP1B1 expressed in yeast cells at 10 uM using 7-etho...
Source: ChEMBL
Target: Cytochrome P450 1B1
External Id: CHEMBL4014745

Name: Inhibition of recombinant human liver CYP1A1 expressed in HEK293 cells at 10 uM using...
Source: ChEMBL
Target: Cytochrome P450 1A1
External Id: CHEMBL4014742

Name: Inhibition of recombinant human liver CYP1B1 expressed in HEK293 cells at 10 uM using...
Source: ChEMBL
Target: Cytochrome P450 1B1
External Id: CHEMBL4014743

Name: Inhibition of N-terminal GST-tagged human TNKS-2 (849 to 1166 residues) expressed in ...
Source: ChEMBL
Target: Poly [ADP-ribose] polymerase tankyrase-2
External Id: CHEMBL3830930

Name: Inhibition of PARP-1 (unknown origin) using histone as substrate incubated for 1 hr b...
Source: ChEMBL
Target: Poly [ADP-ribose] polymerase 1
External Id: CHEMBL3830931

Name: HIV Enzyme Data
Source: NIAID
Target: N/A
External Id: HIV Enzyme Data

Name: Inhibition of human PARP-2 (unknown origin) using histone as substrate incubated for ...
Source: ChEMBL
Target: Poly [ADP-ribose] polymerase 2
External Id: CHEMBL3829027

Name: ASTRAZENECA: Octan-1-ol/water (pH7.4) distribution coefficent measured by a shake fl...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3301363

Name: Inhibition of N-terminal GST-tagged human TNKS-2 (849 to 1166 residues) expressed in ...
Source: ChEMBL
Target: Poly [ADP-ribose] polymerase tankyrase-2
External Id: CHEMBL3829028

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2-<4-Nitro-phenyl>-4-oxo-chinazolin

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 2-(4-Nitrophenyl)Quinazolin-4(1H)-One
Price: Check
Purity: 98.4%
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Shanghai Amole Biotechnology Co., Ltd.
China
Product Name: 2-(4-Nitrophenyl)Quinazolin-4(1H)-One
Price: ￥Inquiry/100mg ￥Inquiry/1g ￥Inquiry/250mg
Purity: 98.0%
Delivery: Inquiry
Contact: Xiyao Wang
Email: 3623107365@qq.com

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Price: ￥550/25 mg

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2-(4-Nitrophenyl)Quinazolin-4(1H)-One

Use of 2-(4-Nitrophenyl)Quinazolin-4(1H)-One

Names

2-(4-Nitrophenyl)Quinazolin-4(1H)-One Biological Activity

Chemical & Physical Properties

2-(4-Nitrophenyl)Quinazolin-4(1H)-OneBioassay

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.