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1670-14-0

1670-14-0 structure
1670-14-0 structure
  • Name: Benzimidamide hydrochloride
  • Chemical Name: Benzamidine hydrochloride
  • CAS Number: 1670-14-0
  • Molecular Formula: C7H9ClN2
  • Molecular Weight: 156.613
  • Catalog: Signaling Pathways Metabolic Enzyme/Protease Ser/Thr Protease
  • Create Date: 2018-04-12 08:00:00
  • Modify Date: 2024-01-02 08:23:55
  • Benzamidine hydrochloride is an reversible competitive inhibitor of trypsin-like serine proteases, with Kis of 97 µM, 21 µM, 20 µM and 110 µM for uPA, trypsin, tryptase and factor Xa, respectively[1].

Name Benzamidine hydrochloride
Synonyms BENZAMIDE HCL H2O
benzenecarboximidamide hydrochloride
EINECS 216-795-4
benzamidinium chloride
benzamidine-hydrochloride
Benzamidine hydrochloride
BENZAMIDINE HCL
2-phenylamidine hydrochloride
Benzenecarboximidamide hydrochloride (1:1)
benzamidine hydroxychloride
Benzamidine hydrochl
MFCD00013025
Additive Screening
Benzamidine monohydrochloride
AMIDINOBENZENE HYDROCHLORIDE
amidinobenzenehydrochloride
Benzamidin Hydrochloride
Amidinobenzene hydrochloride (1:1)
Benzenecarboximidamide, hydrochloride (1:1)
Benzimidamide hydrochloride
phenyl amidine hydrochloride
Description Benzamidine hydrochloride is an reversible competitive inhibitor of trypsin-like serine proteases, with Kis of 97 µM, 21 µM, 20 µM and 110 µM for uPA, trypsin, tryptase and factor Xa, respectively[1].
Related Catalog
Target

Ki: 97 µM (uPA), 21 µM (trypsin), 20 µM (tryptase), 110 µM (factor Xa)[1]

In Vitro Benzamidine hydrochloride has weak inhibition for tPA and thrombin, with Kis of 750 µM and 320 µM, respectively[1].
References

[1]. Tanizawa K, et al. Proteolytic enzymes. VI. Aromatic amidines as competitive inhibitors of trypsin. J Biochem. 1971 May;69(5):893-9.

[2]. Katz BA, et al. Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator. Chem Biol. 2000 Apr;7(4):299-312.

Density 1.09 g/cm3
Boiling Point 332.9ºC at 760 mmHg
Melting Point 86-88 °C(lit.)
Molecular Formula C7H9ClN2
Molecular Weight 156.613
Flash Point 155.1ºC
Exact Mass 156.045425
PSA 49.87000
LogP 2.57270
Vapour Pressure 5.63E-05mmHg at 25°C
Water Solubility soluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CV6260000
CHEMICAL NAME :
Benzamidine, hydrochloride
CAS REGISTRY NUMBER :
1670-14-0
LAST UPDATED :
199701
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C7-H8-N2.Cl-H
MOLECULAR WEIGHT :
156.63
WISWESSER LINE NOTATION :
ZYR&UM &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
580 mg/kg
TOXIC EFFECTS :
Brain and Coverings - meningeal changes Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes
REFERENCE :
BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 20,1045,1979
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319
Precautionary Statements P305 + P351 + P338
Personal Protective Equipment Eyeshields;Gloves
Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S37/39-S36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS CV6260000
HS Code 2925290090

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Literature: Mahajan, Umesh S.; Godinde, Rupesh R.; Mandhare Synthetic Communications, 2011 , vol. 41, # 15 p. 2195 - 2199

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1670-14-0

Literature: Journal of Organometallic Chemistry, , vol. 331, # 2 p. 161 - 168

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1670-14-0 structure

1670-14-0

Literature: Chemical and Pharmaceutical Bulletin, , vol. 55, # 3 p. 372 - 375

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1670-14-0 structure

1670-14-0

Literature: Die Imidoaether und ihre Derivate , S. 152
HS Code 2925290090
Summary 2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%