Name | Benzamidine hydrochloride |
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Synonyms |
BENZAMIDE HCL H2O
benzenecarboximidamide hydrochloride EINECS 216-795-4 benzamidinium chloride benzamidine-hydrochloride Benzamidine hydrochloride BENZAMIDINE HCL 2-phenylamidine hydrochloride Benzenecarboximidamide hydrochloride (1:1) benzamidine hydroxychloride Benzamidine hydrochl MFCD00013025 Additive Screening Benzamidine monohydrochloride AMIDINOBENZENE HYDROCHLORIDE amidinobenzenehydrochloride Benzamidin Hydrochloride Amidinobenzene hydrochloride (1:1) Benzenecarboximidamide, hydrochloride (1:1) Benzimidamide hydrochloride phenyl amidine hydrochloride |
Description | Benzamidine hydrochloride is an reversible competitive inhibitor of trypsin-like serine proteases, with Kis of 97 µM, 21 µM, 20 µM and 110 µM for uPA, trypsin, tryptase and factor Xa, respectively[1]. |
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Related Catalog | |
Target |
Ki: 97 µM (uPA), 21 µM (trypsin), 20 µM (tryptase), 110 µM (factor Xa)[1] |
In Vitro | Benzamidine hydrochloride has weak inhibition for tPA and thrombin, with Kis of 750 µM and 320 µM, respectively[1]. |
References |
Density | 1.09 g/cm3 |
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Boiling Point | 332.9ºC at 760 mmHg |
Melting Point | 86-88 °C(lit.) |
Molecular Formula | C7H9ClN2 |
Molecular Weight | 156.613 |
Flash Point | 155.1ºC |
Exact Mass | 156.045425 |
PSA | 49.87000 |
LogP | 2.57270 |
Vapour Pressure | 5.63E-05mmHg at 25°C |
Water Solubility | soluble |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
Symbol |
GHS07 |
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Signal Word | Warning |
Hazard Statements | H315-H319 |
Precautionary Statements | P305 + P351 + P338 |
Personal Protective Equipment | Eyeshields;Gloves |
Hazard Codes | Xi:Irritant; |
Risk Phrases | R36/37/38 |
Safety Phrases | S26-S37/39-S36 |
RIDADR | NONH for all modes of transport |
WGK Germany | 3 |
RTECS | CV6260000 |
HS Code | 2925290090 |
~75% 1670-14-0 |
Literature: Mahajan, Umesh S.; Godinde, Rupesh R.; Mandhare Synthetic Communications, 2011 , vol. 41, # 15 p. 2195 - 2199 |
~% 1670-14-0 |
Literature: Journal of Organometallic Chemistry, , vol. 331, # 2 p. 161 - 168 |
~% 1670-14-0 |
Literature: Chemical and Pharmaceutical Bulletin, , vol. 55, # 3 p. 372 - 375 |
~% 1670-14-0 |
Literature: Die Imidoaether und ihre Derivate |
Precursor 5 | |
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DownStream 9 | |
HS Code | 2925290090 |
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Summary | 2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |