2196-18-1

2196-18-1 structure

Name: Propiophenone, 3,4'-dihydroxy-3'-methoxy-
Chemical Name: 3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)propan-1-one
CAS Number: 2196-18-1
Molecular Formula: C₁₀H₁₂O₄
Molecular Weight: 196.200
Catalog: Natural product Phenylpropanoid
Create Date: 2016-04-18 13:44:48
Modify Date: 2024-01-30 12:21:41
β-Hydroxypropiovanillone, a natural compound, shows significant concentration-dependent inhibitory effects on α-glucosidase with an IC50 of 257.8 μg/mL[1].

Name	3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)propan-1-one
Synonyms	Propiophenone,3,4'-dihydroxy-3'-methoxy 3-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-1-propanone 1-Propanone, 3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)- Propiophenone, 3,4'-dihydroxy-3'-methoxy-

Description	β-Hydroxypropiovanillone, a natural compound, shows significant concentration-dependent inhibitory effects on α-glucosidase with an IC50 of 257.8 μg/mL[1].
Related Catalog	Research Areas >> Cardiovascular Disease
Target	IC50: 257.8 μg/mL (α-glucosidase)[1]
In Vitro	β-hydroxypropiovanillone and its analogs can be obtained by chemoselective catalytic oxidation of lignin using 2,3-dichloro-5,6-dicyano-1,4-benzoquinone/tert-butyl nitrite/O2, followed by cleavage of arylglycerol-β-aryl ether with zinc[2]. In SYK-6 cells, β-hydroxypropiovanillone (HPV) is oxidized to vanilloyl acetic acid (VAA) via vanilloyl acetaldehyde (VAL). The resulting VAA was further converted into vanillate through the activation of VAA by coenzyme A[3].
References	[1]. Lv Q , et al. Dihydrochalcone-derived polyphenols from tea crab apple (Malus hupehensis) and their inhibitory effects on α-glucosidase in vitro. Food Funct. 2019;10(5):2881-2887. [2]. Higuchi Y, et al. Bacterial Catabolism of β-Hydroxypropiovanillone and β-Hydroxypropiosyringone Produced in the Reductive Cleavage of Arylglycerol-β-Aryl Ether in Lignin. Appl Environ Microbiol. 2018;84(7):e02670-17. Published 2018 Mar 19. [3]. Higuchi Y, et al. Discovery of novel enzyme genes involved in the conversion of an arylglycerol-β-aryl ether metabolite and their use in generating a metabolic pathway for lignin valorization. Metab Eng. 2019;55:258-267.

Hazard Codes	Xi
HS Code	2914509090

7382-59-4

~27%

2196-18-1

90-05-1

498-02-2

Literature: Crestini, Claudia; D'Auria, Maurizio Tetrahedron, 1997 , vol. 53, # 23 p. 7877 - 7888

1835-11-6

2196-18-1

Literature: Crestini, Claudia; D'Auria, Maurizio Tetrahedron, 1997 , vol. 53, # 23 p. 7877 - 7888

22317-34-6

2196-18-1

Literature: Crestini, Claudia; D'Auria, Maurizio Tetrahedron, 1997 , vol. 53, # 23 p. 7877 - 7888

1835-12-7

2196-18-1

Literature: Crestini, Claudia; D'Auria, Maurizio Tetrahedron, 1997 , vol. 53, # 23 p. 7877 - 7888

22317-29-9

2196-18-1

Literature: Crestini, Claudia; D'Auria, Maurizio Tetrahedron, 1997 , vol. 53, # 23 p. 7877 - 7888

HS Code	2914509090
Summary	HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%