1001438-96-5

1001438-96-5 structure

Name: AMG-076
Chemical Name: 1-[2-[(4aR,11R,11aS)-11-methyl-9-(trifluoromethyl)-1,3,4,4a,5,6,11,11a-octahydropyrido[4,3-b]carbazol-2-yl]ethyl]cyclohexane-1-carboxylic acid,benzenesulfonic acid
CAS Number: 1001438-96-5
Molecular Formula: C₃₂H₃₉F₃N₂O₅S
Molecular Weight: 620.72300
Catalog: Signaling Pathways GPCR/G Protein MCHR1 (GPR24)
Create Date: 2016-08-30 15:14:23
Modify Date: 2024-01-09 05:28:31
AMG-076 is an orally bioavailable and selective MCHR1 antagonist. AMG-076 results in significant reduction in body weight gain in nonobese mice fed a high-fat diet and in high-fat diet-induced obese (DIO) mice[1].

Name	1-[2-[(4aR,11R,11aS)-11-methyl-9-(trifluoromethyl)-1,3,4,4a,5,6,11,11a-octahydropyrido[4,3-b]carbazol-2-yl]ethyl]cyclohexane-1-carboxylic acid,benzenesulfonic acid
Synonyms	unii-ogb0t3ag23 amg 076

Description	AMG-076 is an orally bioavailable and selective MCHR1 antagonist. AMG-076 results in significant reduction in body weight gain in nonobese mice fed a high-fat diet and in high-fat diet-induced obese (DIO) mice[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> MCHR1 (GPR24) Research Areas >> Metabolic Disease
References	[1]. Alykhan S Motani, et al. Evaluation of AMG 076, a potent and selective MCHR1 antagonist, in rodent and primate obesity models. Pharmacol Res Perspect. 2013 Oct;1(1):e00003.