AMG-076

Modify Date: 2024-01-09 05:28:31

AMG-076 Structure
AMG-076 structure
Common Name AMG-076
CAS Number 1001438-96-5 Molecular Weight 620.72300
Density N/A Boiling Point N/A
Molecular Formula C32H39F3N2O5S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of AMG-076


AMG-076 is an orally bioavailable and selective MCHR1 antagonist. AMG-076 results in significant reduction in body weight gain in nonobese mice fed a high-fat diet and in high-fat diet-induced obese (DIO) mice[1].

 Names

Name 1-[2-[(4aR,11R,11aS)-11-methyl-9-(trifluoromethyl)-1,3,4,4a,5,6,11,11a-octahydropyrido[4,3-b]carbazol-2-yl]ethyl]cyclohexane-1-carboxylic acid,benzenesulfonic acid
Synonym More Synonyms

 AMG-076 Biological Activity

Description AMG-076 is an orally bioavailable and selective MCHR1 antagonist. AMG-076 results in significant reduction in body weight gain in nonobese mice fed a high-fat diet and in high-fat diet-induced obese (DIO) mice[1].
Related Catalog
References

[1]. Alykhan S Motani, et al. Evaluation of AMG 076, a potent and selective MCHR1 antagonist, in rodent and primate obesity models. Pharmacol Res Perspect. 2013 Oct;1(1):e00003.  

 Chemical & Physical Properties

Molecular Formula C32H39F3N2O5S
Molecular Weight 620.72300
Exact Mass 620.25300
PSA 119.08000
LogP 8.16160

 Synonyms

unii-ogb0t3ag23
amg 076
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