38537-24-5

38537-24-5 structure

Name: (1,2,3,4,5,6,7,8-2H8)-9H-Carbazole
Chemical Name: carbazole-d8
CAS Number: 38537-24-5
Molecular Formula: C₁₂HD₈N
Molecular Weight: 175.256
Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
Create Date: 2018-02-17 08:00:00
Modify Date: 2024-01-11 18:10:42
Carbazole-d8 is the deuterium labeled Carbazole (HY-D0204). Carbazole is a tricyclic aromatic heterocyclic. Carbazole can form a new type of DNA minor groove complex to suppress the synthesis of new DNA or RNA[1][2].

Name	carbazole-d8
Synonyms	(1,2,3,4,5,6,7,8-H)-9H-Carbazole carbazole d8 9H-Carbazole-1,2,3,4,5,6,7,8-d carbazole-d8,nh

Description	Carbazole-d8 is the deuterium labeled Carbazole (HY-D0204). Carbazole is a tricyclic aromatic heterocyclic. Carbazole can form a new type of DNA minor groove complex to suppress the synthesis of new DNA or RNA[1][2].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Research Areas >> Others
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. F A Tanious, et al. A new type of DNA minor-groove complex: carbazole dication-DNA interactions. Biochemistry. 1997 Dec 9;36(49):15315-25.