38537-24-5

38537-24-5 structure
38537-24-5 structure
  • Name: (1,2,3,4,5,6,7,8-2H8)-9H-Carbazole
  • Chemical Name: carbazole-d8
  • CAS Number: 38537-24-5
  • Molecular Formula: C12HD8N
  • Molecular Weight: 175.256
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
  • Create Date: 2018-02-17 08:00:00
  • Modify Date: 2024-01-11 18:10:42
  • Carbazole-d8 is the deuterium labeled Carbazole (HY-D0204). Carbazole is a tricyclic aromatic heterocyclic. Carbazole can form a new type of DNA minor groove complex to suppress the synthesis of new DNA or RNA[1][2].

Name carbazole-d8
Synonyms (1,2,3,4,5,6,7,8-H)-9H-Carbazole
carbazole d8
9H-Carbazole-1,2,3,4,5,6,7,8-d
carbazole-d8,nh
Description Carbazole-d8 is the deuterium labeled Carbazole (HY-D0204). Carbazole is a tricyclic aromatic heterocyclic. Carbazole can form a new type of DNA minor groove complex to suppress the synthesis of new DNA or RNA[1][2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. F A Tanious, et al. A new type of DNA minor-groove complex: carbazole dication-DNA interactions. Biochemistry. 1997 Dec 9;36(49):15315-25.  

Density 1.2±0.1 g/cm3
Boiling Point 355.0±11.0 °C at 760 mmHg
Molecular Formula C12HD8N
Molecular Weight 175.256
Flash Point 160.0±11.9 °C
Exact Mass 175.123718
PSA 15.79000
LogP 3.72
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.768