(1,2,3,4,5,6,7,8-2H8)-9H-Carbazole

Modify Date: 2024-01-11 18:10:42

(1,2,3,4,5,6,7,8-2H8)-9H-Carbazole Structure
(1,2,3,4,5,6,7,8-2H8)-9H-Carbazole structure
Common Name (1,2,3,4,5,6,7,8-2H8)-9H-Carbazole
CAS Number 38537-24-5 Molecular Weight 175.256
Density 1.2±0.1 g/cm3 Boiling Point 355.0±11.0 °C at 760 mmHg
Molecular Formula C12HD8N Melting Point N/A
MSDS N/A Flash Point 160.0±11.9 °C

 Use of (1,2,3,4,5,6,7,8-2H8)-9H-Carbazole


Carbazole-d8 is the deuterium labeled Carbazole (HY-D0204). Carbazole is a tricyclic aromatic heterocyclic. Carbazole can form a new type of DNA minor groove complex to suppress the synthesis of new DNA or RNA[1][2].

 Names

Name carbazole-d8
Synonym More Synonyms

 (1,2,3,4,5,6,7,8-2H8)-9H-Carbazole Biological Activity

Description Carbazole-d8 is the deuterium labeled Carbazole (HY-D0204). Carbazole is a tricyclic aromatic heterocyclic. Carbazole can form a new type of DNA minor groove complex to suppress the synthesis of new DNA or RNA[1][2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. F A Tanious, et al. A new type of DNA minor-groove complex: carbazole dication-DNA interactions. Biochemistry. 1997 Dec 9;36(49):15315-25.  

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 355.0±11.0 °C at 760 mmHg
Molecular Formula C12HD8N
Molecular Weight 175.256
Flash Point 160.0±11.9 °C
Exact Mass 175.123718
PSA 15.79000
LogP 3.72
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.768

 Synonyms

(1,2,3,4,5,6,7,8-H)-9H-Carbazole
carbazole d8
9H-Carbazole-1,2,3,4,5,6,7,8-d
carbazole-d8,nh