35773-42-3
35773-42-3 structure
- Name: EMI1
- Chemical Name: 3-(2-benzoxazolyl)-7-(diethylamino)-2H-1-benzopyran-2-one
- CAS Number: 35773-42-3
- Molecular Formula: C20H18N2O3
- Molecular Weight: 334.36900
- Catalog: Signaling Pathways JAK/STAT Signaling EGFR
- Create Date: 2016-08-02 03:48:19
- Modify Date: 2024-01-11 09:37:34
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EMI1 is an EGFR ex19del/T790M/C797S and EGFR L858R/T790M/C797S inhibitor[1].
| Name | 3-(2-benzoxazolyl)-7-(diethylamino)-2H-1-benzopyran-2-one |
|---|---|
| Synonyms |
3-benzooxazol-2-yl-7-diethylamino-chromen-2-one
3-(1,3-BENZOXAZOL-2-YL)-7-(DIETHYLAMINO)-2H-CHROMEN-2-ONE |
| Description | EMI1 is an EGFR ex19del/T790M/C797S and EGFR L858R/T790M/C797S inhibitor[1]. |
|---|---|
| Related Catalog | |
| Target |
EGFRdel19 T790M C797S EGFRL858R/T790M/C797S |
| In Vitro | EMI1 inhibits PC9 EGFR ex19del/T790M/C797S organoid growth with the EC50 of 131 nM[1]. EMI1 (1 nM-10 μM) potently reduces the interaction of EGFR triple mutant with Shc1[1]. EMI1 (1 nM-100μM) strongly inhibits the viability and increase the caspase 3/7 activity of PC9 EGFR ex19del/T790M/C797S triple-mutant cells than noncancerous human bronchial epithelial (HBE) cells[1]. Cell Viability Assay[1] Cell Line: PC9 EGFR ex19del/T790M/C797S and HBE bronchial epithelial lung EGFR-WT control cells. Concentration: 0.001, 0.01, 0.1, 1, 10, 100 μM Incubation Time: 72 hours Result: Strongly inhibited the viability. |
| References |
| Molecular Formula | C20H18N2O3 |
|---|---|
| Molecular Weight | 334.36900 |
| Exact Mass | 334.13200 |
| PSA | 59.48000 |
| LogP | 4.44740 |
| HS Code | 2934999090 |
|---|
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |