EMI1
Modify Date: 2024-01-11 09:37:34
EMI1 structure
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Common Name | EMI1 | ||
|---|---|---|---|---|
| CAS Number | 35773-42-3 | Molecular Weight | 334.36900 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H18N2O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of EMI1EMI1 is an EGFR ex19del/T790M/C797S and EGFR L858R/T790M/C797S inhibitor[1]. |
| Name | 3-(2-benzoxazolyl)-7-(diethylamino)-2H-1-benzopyran-2-one |
|---|---|
| Synonym | More Synonyms |
| Description | EMI1 is an EGFR ex19del/T790M/C797S and EGFR L858R/T790M/C797S inhibitor[1]. |
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| Related Catalog | |
| Target |
EGFRdel19 T790M C797S EGFRL858R/T790M/C797S |
| In Vitro | EMI1 inhibits PC9 EGFR ex19del/T790M/C797S organoid growth with the EC50 of 131 nM[1]. EMI1 (1 nM-10 μM) potently reduces the interaction of EGFR triple mutant with Shc1[1]. EMI1 (1 nM-100μM) strongly inhibits the viability and increase the caspase 3/7 activity of PC9 EGFR ex19del/T790M/C797S triple-mutant cells than noncancerous human bronchial epithelial (HBE) cells[1]. Cell Viability Assay[1] Cell Line: PC9 EGFR ex19del/T790M/C797S and HBE bronchial epithelial lung EGFR-WT control cells. Concentration: 0.001, 0.01, 0.1, 1, 10, 100 μM Incubation Time: 72 hours Result: Strongly inhibited the viability. |
| References |
| Molecular Formula | C20H18N2O3 |
|---|---|
| Molecular Weight | 334.36900 |
| Exact Mass | 334.13200 |
| PSA | 59.48000 |
| LogP | 4.44740 |
| HS Code | 2934999090 |
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| HS Code | 2934999090 |
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| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| 3-benzooxazol-2-yl-7-diethylamino-chromen-2-one |
| 3-(1,3-BENZOXAZOL-2-YL)-7-(DIETHYLAMINO)-2H-CHROMEN-2-ONE |