139339-45-0

139339-45-0 structure

Name: Ro 24-7429
Chemical Name: 7-Chloro-N-Methyl-5-(1H-Pyrrol-2-Yl)-3H-1,4-Benzodiazepin-2-Amine
CAS Number: 139339-45-0
Molecular Formula: C₁₄H₁₃ClN₄
Molecular Weight: 272.73300
Catalog: Signaling Pathways Anti-infection HIV
Create Date: 2018-12-27 19:39:20
Modify Date: 2024-01-13 01:20:20
Ro24-7429 is a potent and orally active HIV-1 transactivator protein Tat antagonist. Ro24-7429 is also a runt-related transcription factor 1 (RUNX1) inhibitor. Ro24-7429 has anti-HIV, antifibrotic and anti-inflammatory effects[1][2].

Name	7-Chloro-N-Methyl-5-(1H-Pyrrol-2-Yl)-3H-1,4-Benzodiazepin-2-Amine
Synonyms	Ro 24-7429 Aids003055 [7-Chloro-5-(1H-Pyrrol-2-Yl)-3H-1,4-Benzodiazepin-2-Yl]-Methyl-Amine Aids-003055

Description	Ro24-7429 is a potent and orally active HIV-1 transactivator protein Tat antagonist. Ro24-7429 is also a runt-related transcription factor 1 (RUNX1) inhibitor. Ro24-7429 has anti-HIV, antifibrotic and anti-inflammatory effects[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection Research Areas >> Inflammation/Immunology
In Vitro	Ro 24-7429 (0.1-5 μM; 3 days) induces apoptosis of cultured PBMCs in a dose-dependent manner[1]. Ro 24-7429 (1-25 μM) also induces apoptosis and inhibits antigen-induced lymphocyte proliferation[1]. Ro24-7429 (50-200 μM; 24-72 hours) strongly inhibits the proliferation of A549 and HLF cells in a dose-dependent manner. Ro24-7429 treatment (75 μM) significantly reduces TNF-α-induced up-regulation of RUNX1 mRNA by 50% at 48 hours[2]. Apoptosis Analysis[1] Cell Line: Peripheral blood mononuclear cells (PBMCs) Concentration: 0.1 μM, 1 μM, 5 μM Incubation Time: 3 days Result: Induced a dose-dependent increase in apoptosis of cultured PBMCs.
In Vivo	Ro24-7429 (17.5-70 mg/kg; i.p.; daily; for 14 or 21 days) treatment robustly ameliorates lung fibrosis and inflammation in the Bleomycin-induced pulmonary fibrosis (PF) mouse model. Ro24-7429 curbs expression of fibrosis markers in injured mouse lungs[2]. Animal Model: C57BL/6J male and female mice (aged 6 to 8 weeks) induced by Bleomycin[2] Dosage: 17.5 mg/kg, 35 mg/kg, and 70 mg/kg Administration: i.p.; daily; for 14 or 21 days Result: Ameliorated lung fibrosis and inflammation in the Bleomycin-induced PF mouse model.
References	[1]. A H Patki, et al. HIV-1 Tat protein and its inhibitor Ro 24-7429 inhibit lymphocyte proliferation and induce apoptosis in peripheral blood mononuclear cells from healthy donors. Cell Immunol. 1996 Apr 10;169(1):40-6. [2]. Michael O'Hare, et al. Targeting Runt-Related Transcription Factor 1 Prevents Pulmonary Fibrosis and Reduces Expression of Severe Acute Respiratory Syndrome Coronavirus 2 Host Mediators. Am J Pathol. 2021 Jul;191(7):1193-1208.

Density	1.36g/cm3
Boiling Point	514.6°C(760mmHg),计算值
Molecular Formula	C₁₄H₁₃ClN₄
Molecular Weight	272.73300
Flash Point	265°C
Exact Mass	272.08300
PSA	52.54000
LogP	2.03060

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