1265789-88-5

1265789-88-5 structure

Name: S6K-18
Chemical Name: 2-(3-(1H-indazol-5-yl)ureido)-5-tert-butylthiophene-3-carboxylic acid
CAS Number: 1265789-88-5
Molecular Formula: C₁₇H₁₈N₄O₃S
Molecular Weight: 358.41
Catalog: Signaling Pathways MAPK/ERK Pathway Ribosomal S6 Kinase (RSK)
Create Date: 2016-02-24 05:46:06
Modify Date: 2026-07-01 18:12:57
S6K-18 is a potent and selective p70S6K1 inhibitor with an IC50 of 52 nM[1].

Name	2-(3-(1H-indazol-5-yl)ureido)-5-tert-butylthiophene-3-carboxylic acid
Synonyms	S6K1-IN-1 S6K-18, 10 mM in DMSO 2-[(1H-Indazol-5-ylcarbamoyl)amino]-5-(2-methyl-2-propanyl)-3-thiophenecarboxylic acid S6K-18 >= 3-Thiophenecboxylic acid, 5-(1,1-dimethylethyl)-2-[[(1H-indazol-5-ylamino)carbonyl]amino] S6K18,S6K,Ribosomal S6 Kinase (RSK),Inhibitor,S6K 18,S-6K-18,inhibit 2-(3-(1H-Indazol-5-yl)ureido)-5-(tert-butyl)thiophene-3-cboxylic acid

Description	S6K-18 is a potent and selective p70S6K1 inhibitor with an IC50 of 52 nM[1].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> MAPK/ERK Pathway >> Ribosomal S6 Kinase (RSK)
Target	S6K1:52 nM (IC50)
References	[1]. Ye P, et al. Potent and selective thiophene urea-templated inhibitors of S6K. Bioorg Med Chem Lett. 2011 Jan 15;21(2):849-52.