510-30-5

510-30-5 structure

Name: Echinocystic acid
Chemical Name: echinocystic acid
CAS Number: 510-30-5
Molecular Formula: C₃₀H₄₈O₄
Molecular Weight: 472.700
Catalog: Biochemical Chinese herbal medicine ingredients
Create Date: 2018-07-30 11:25:15
Modify Date: 2024-01-02 18:08:46
Echinocystic acid a pentacyclic triterpene isolated from the fruits of Gleditsia sinensis Lam, has potent antioxidant, anti-inflammatory and anti-tumor properties. In vitro: Echinocystic acid (EA) inhibit the formation of osteoclast. EA inhibit RANKL-induced NF-κB activation and ERK phosphorylation in BMMs. [1] EA inhibit IL-1β-induced inflammation in chondrocytes. [2]In vivo: Echinocystic acid reduces reserpine-induced pain/depression dyad in mice. [3]

Name	echinocystic acid
Synonyms	(4aR,5R,6aS,6bR,8aR,10S,12aR,12bR,14bS)-5,10-Dihydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydro-4a(2H)-picenecarboxylic acid Echicystic acid (3β,16α)-3,16-Dihydroxyolean-12-en-28-oic acid Albizziagenin Echinocystsaeure 3-B,16-A-DIHYDROXYOLEAN-12-EN-28-OIC ACID echinaystic acid Olean-12-en-28-oic acid, 3,16-dihydroxy-, (3β,16α)- Echinocystic

Description	Echinocystic acid a pentacyclic triterpene isolated from the fruits of Gleditsia sinensis Lam, has potent antioxidant, anti-inflammatory and anti-tumor properties. In vitro: Echinocystic acid (EA) inhibit the formation of osteoclast. EA inhibit RANKL-induced NF-κB activation and ERK phosphorylation in BMMs. [1] EA inhibit IL-1β-induced inflammation in chondrocytes. [2]In vivo: Echinocystic acid reduces reserpine-induced pain/depression dyad in mice. [3]
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Natural Products >> Terpenoids and Glycosides
References	[1]. Yang JH et al. Echinocystic acid inhibits RANKL-induced osteoclastogenesis by regulating NF-κB and ERK signaling pathways. Biochem Biophys Res Commun. 2016 Sep 2;477(4):673-7. [2]. Ma Z et al. Echinocystic Acid Inhibits IL-1β-Induced COX-2 and iNOS Expression in Human Osteoarthritis Chondrocytes. Inflammation. 2016 Apr;39(2):543-9. [3]. Li S et al. Echinocystic acid reduces reserpine-induced pain/depression dyad in mice. Metab Brain Dis. 2016 Apr;31(2):455-63.