Echinocystic acid

Modify Date: 2024-01-02 18:08:46

Echinocystic acid Structure
Echinocystic acid structure
 Common Name Echinocystic acid
CAS Number 510-30-5 Molecular Weight 472.700
Density 1.1±0.1 g/cm3 Boiling Point 585.0±50.0 °C at 760 mmHg
Molecular Formula C30H48O4 Melting Point 299-300ºC
MSDS N/A Flash Point 321.6±26.6 °C

 Use of Echinocystic acid


Echinocystic acid a pentacyclic triterpene isolated from the fruits of Gleditsia sinensis Lam, has potent antioxidant, anti-inflammatory and anti-tumor properties. In vitro: Echinocystic acid (EA) inhibit the formation of osteoclast. EA inhibit RANKL-induced NF-κB activation and ERK phosphorylation in BMMs. [1] EA inhibit IL-1β-induced inflammation in chondrocytes. [2]In vivo: Echinocystic acid reduces reserpine-induced pain/depression dyad in mice. [3]

 Names

Name echinocystic acid
Synonym More Synonyms

 Echinocystic acid Biological Activity

Description Echinocystic acid a pentacyclic triterpene isolated from the fruits of Gleditsia sinensis Lam, has potent antioxidant, anti-inflammatory and anti-tumor properties. In vitro: Echinocystic acid (EA) inhibit the formation of osteoclast. EA inhibit RANKL-induced NF-κB activation and ERK phosphorylation in BMMs. [1] EA inhibit IL-1β-induced inflammation in chondrocytes. [2]In vivo: Echinocystic acid reduces reserpine-induced pain/depression dyad in mice. [3]
Related Catalog
References

[1]. Yang JH et al. Echinocystic acid inhibits RANKL-induced osteoclastogenesis by regulating NF-κB and ERK signaling pathways. Biochem Biophys Res Commun. 2016 Sep 2;477(4):673-7.

[2]. Ma Z et al. Echinocystic Acid Inhibits IL-1β-Induced COX-2 and iNOS Expression in Human Osteoarthritis Chondrocytes. Inflammation. 2016 Apr;39(2):543-9.

[3]. Li S et al. Echinocystic acid reduces reserpine-induced pain/depression dyad in mice. Metab Brain Dis. 2016 Apr;31(2):455-63.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 585.0±50.0 °C at 760 mmHg
Melting Point 299-300ºC
Molecular Formula C30H48O4
Molecular Weight 472.700
Flash Point 321.6±26.6 °C
Exact Mass 472.355255
PSA 77.76000
LogP 7.58
Vapour Pressure 0.0±3.7 mmHg at 25°C
Index of Refraction 1.568
Storage condition 2-8C

 Synonyms

(4aR,5R,6aS,6bR,8aR,10S,12aR,12bR,14bS)-5,10-Dihydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydro-4a(2H)-picenecarboxylic acid
Echicystic acid
(3β,16α)-3,16-Dihydroxyolean-12-en-28-oic acid
Albizziagenin
Echinocystsaeure
3-B,16-A-DIHYDROXYOLEAN-12-EN-28-OIC ACID
echinaystic acid
Olean-12-en-28-oic acid, 3,16-dihydroxy-, (3β,16α)-
Echinocystic
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