2156-29-8

2156-29-8 structure

Name: 2-di-1-asp
Chemical Name: 2-[4-(dimethylamino)styryl]-1-methylpyridinium iodide
CAS Number: 2156-29-8
Molecular Formula: C₁₆H₁₉IN₂
Molecular Weight: 366.24000
Catalog: Pharmaceutical intermediate Heterocyclic compound Pyridine compound Methylpyridine
Create Date: 2018-12-24 15:36:03
Modify Date: 2024-01-04 12:02:36
2-Di-1-ASP (Compound 18a) is a mono-stryryl dye, and widely used as mitochondrial stain and groove-binding fluorescent probes for double-stranded DNA. 2-Di-1-ASP is selective for G-quadruplex (G4) and double-stranded DNA[1].

Name	2-[4-(dimethylamino)styryl]-1-methylpyridinium iodide
Synonyms	D-308 2-{2-[4-(dimethylamino)phenyl]ethenyl}-1-methylpyridinium iodide 2m2Pm 2-(4-(Dimethylamino)styryl)-N-methylpyridinium MFCD00011980 o-DPD 2-<4-(dimethylamino)styryl>-1-ethylpyridinium iodide 2-(4-(dimethylamino)styryl)-1-methylpyridinium (E)-2-(4-(dimethylamino)styryl)-1-methylpyridinium iodide 2-(4-DIMETHYLAMINOSTYRYL)-1-METHYLPYRIDINIUM IODIDE 2-DI-1-ASP EINECS 218-460-8 1-METHYL-2-P-DIMETHYLAMINO-STYRYL-PYRIDINIUM-IODIDE

Description	2-Di-1-ASP (Compound 18a) is a mono-stryryl dye, and widely used as mitochondrial stain and groove-binding fluorescent probes for double-stranded DNA. 2-Di-1-ASP is selective for G-quadruplex (G4) and double-stranded DNA[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	2-Di-1-ASP (Compound 18a) displays significant fluorescence enhancements in the presence of G-quadruplex (G4) structures (up to 300-fold), and good selectivity with respect to double-stranded DNA. 2-Di-1-ASP shows fluorimetric selectivity for parallel G4-DNA forms (c-kit2, c-kit87up, c-myc)[1].
References	[1]. Xie X, et al. Identification of optimal fluorescent probes for G-quadruplex nucleic acids through systematic exploration of mono- and distyryl dye libraries. Beilstein J Org Chem. 2019 Aug 6;15:1872-1889.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	26-36
RIDADR	NONH for all modes of transport
WGK Germany	3