6681-15-8

6681-15-8 structure

Name: Jatrorrhizine Hydrochloride
Chemical Name: jatrorrhizine hcl(rg)
CAS Number: 6681-15-8
Molecular Formula: C₂₀H₂₀ClNO₄
Molecular Weight: 374.83800
Catalog: Biochemical Plant extracts
Create Date: 2018-09-20 18:19:46
Modify Date: 2024-01-02 19:15:39
Jatrorrhizine chloride is a potent and orally active uptake-2 transporter inhibitor, it can be isolated from various Chinese medicinal plants[1]. Jatrorrhizine chloride exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of MAPK pathway in HT22 hippocampal neurons[2].

Name	jatrorrhizine hcl(rg)
Synonyms	Jatorrhizine,chloride 3-Hydroxy-2,9,10-trimethoxy-5,6-dihydro-isochino[3,2-a]isochinolinylium,Chlorid Jatrorrhizine chloride 3-hydroxy-2,9,10-trimethoxy-5,6-dihydro-isoquino[3,2-a]isoquinolinylium,chloride JatrorrhizineHydrochloride Neprotine chloride Jatrochizine chloride Jatrorrhizine Hydrochloride

Description	Jatrorrhizine chloride is a potent and orally active uptake-2 transporter inhibitor, it can be isolated from various Chinese medicinal plants[1]. Jatrorrhizine chloride exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of MAPK pathway in HT22 hippocampal neurons[2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
Target	Uptake-2 transporter[1]
In Vitro	Organic cation transporters (OCTs) and the plasma membrane monoamine transporter (PMAT) are major uptake-2 transporters[1]. Jatrorrhizine chloride significantly inhibits the plasma membrane monoamine transporter (PMAT) -mediated MPP+ uptake in a concentration-dependent manner with an IC50 value of 1.05 μM[1]. Jatrorrhizine chloride demonstrates a more powerful inhibition on serotonin (5-HT) and norepinephrine (NE) uptake mediated by hOCT2 and hOCT3 than that mediated by PMAT[1]. Jatrorrhizine chloride attenuates the H2O2-induced Bcl-2/Bax ratio reduction and caspase-3 activation in these neurons[2].
References	[1]. Sun S, et al. Jatrorrhizine reduces 5-HT and NE uptake via inhibition of uptake-2 transporters and produces antidepressant-like action in mice. Xenobiotica. 2019 Oct;49(10):1237-1243.