120373-36-6
120373-36-6 structure
- Name: Unoprostone
- Chemical Name: unoprostone
- CAS Number: 120373-36-6
- Molecular Formula: C22H38O5
- Molecular Weight: 382.534
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
- Create Date: 2018-03-18 08:00:00
- Modify Date: 2025-08-26 19:20:50
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Unoprostone, a prostaglandin F2α analogs (PGAs), activates BK channels to reduce oxidative stress- and light-induced retinal cell death, and phagocytotic dysfunction. Unoprostone reduces intraocular pressure and is used topically for glaucoma or ocular hypertension[1].
| Name | unoprostone |
|---|---|
| Synonyms |
[1R-[1a(Z),2b,3a,5a]]-7-[3,5-Dihydroxy-2-(3-oxodecyl)cyclopentyl]-5-heptenoic acid
13,14-Dihydro-15-keto-20-ethyl-PGF2a Unoprostone 13,14-DIHYDRO-15-KETO-20-ETHYL PROSTAGLANDIN F2ALPHA Unii-6X4F561V3w (5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-(3-oxodecyl)cyclopentyl]-5-heptenoic acid 9ALPHA,11ALPHA-DIHYDROXY-15-OXO-20A,20B-DIHOMOPROST-5-EN-1-OIC ACID |
| Description | Unoprostone, a prostaglandin F2α analogs (PGAs), activates BK channels to reduce oxidative stress- and light-induced retinal cell death, and phagocytotic dysfunction. Unoprostone reduces intraocular pressure and is used topically for glaucoma or ocular hypertension[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Pretreatment with Unoprostone (0.01, 0.1, 1 μM; 1 h before H2O2 treatment) protects against H2O2-induced cell death in a concentration-dependent manner and the effect is significant at 0.1 μM and 1 μM concentrations[1]. Pretreatment with Unoprostone at concentrations of 0.1 to 3 μM protects against light-induced cell death in a concentration-dependent manner; the effect is significant at the 1 and 3 μM concentrations. Unoprostone reduces the morphological change, and it significantly inhibits the low mitochondrial membrane potential and cell death induced by light irradiation[1]. Unoprostone has prostaglandin F2α receptors (FP) binding affinity with a Ki of 3.86 μM[2]. Cell Viability Assay[1] Cell Line: H2O2-induced photoreceptor cell Concentration: 0.01, 0.1, 1 μM Incubation Time: 1 hour before H2O2 treatment Result: Protected against H2O2-induced cell death in a concentration-dependent manner. |
| In Vivo | Unoprostone (0.06%, 0.12%; topical instillation; 3 µl) reduces mouse intraocular pressure (IOP) in a dose-dependent manner[3]. Animal Model: Male mice (6 weeks old)[3] Dosage: 0.06%, 0.12% Administration: Topical instillation; 3 µl Result: Reduced mouse IOP in a dose-dependent manner. |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 562.9±40.0 °C at 760 mmHg |
| Molecular Formula | C22H38O5 |
| Molecular Weight | 382.534 |
| Flash Point | 308.3±23.8 °C |
| Exact Mass | 382.271912 |
| PSA | 94.83000 |
| LogP | 3.19 |
| Vapour Pressure | 0.0±3.5 mmHg at 25°C |
| Index of Refraction | 1.509 |