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3766-81-2

3766-81-2 structure
3766-81-2 structure
  • Name: Fenobucarb
  • Chemical Name: fenobucarb
  • CAS Number: 3766-81-2
  • Molecular Formula: C12H17NO2
  • Molecular Weight: 207.269
  • Catalog: Chemical pesticide Insecticide Carbamate insecticide
  • Create Date: 2018-09-10 20:36:17
  • Modify Date: 2024-01-04 21:00:51
  • Fenobucarb is an extensively used carbamate insecticide. Fenobucarb induces zebrafish developmental neurotoxicity through pathways involved in inflammation, oxidative stress, degeneration and apoptosis. Fenobucarb is a possible risk factor to cardiovascular and cerebrovascular systems in animals[1][2].

Name fenobucarb
Synonyms (RS)-2-sec-butylphenyl methylcarbamate
Fenobucarb
Phenol, 2-(1-methylpropyl)-, methylcarbamate
Carvil
EINECS 223-188-8
Fenocarb
(2-butan-2-ylphenyl) N-methylcarbamate
2-sec-Butylphenyl methylcarbamate
Bassa
2-(1-methylpropyl)phenyl methylcarbamate
Osbac
rac-2-[(2R)-butan-2-yl]phenyl methylcarbamate
Baycarb
Hopcin
O-(sec-butyl)phenyl N-methylcarbamate
fenobcarb
2-sec-butyl-phenyl N-methyl-carbamate
2-(butan-2-yl)phenyl methylcarbamate
MFCD00053081
Barizon
BPMC
2-(1-methylpropyl)phenyl N-methylcarbamate
2-(Sec-butyl)phenyl methylcarbamate
Description Fenobucarb is an extensively used carbamate insecticide. Fenobucarb induces zebrafish developmental neurotoxicity through pathways involved in inflammation, oxidative stress, degeneration and apoptosis. Fenobucarb is a possible risk factor to cardiovascular and cerebrovascular systems in animals[1][2].
Related Catalog
References

[1]. Xiao-Yu Zhu, et al. Fenobucarb-induced developmental neurotoxicity and mechanisms in zebrafish. Neurotoxicology. 2020 Jul;79:11-19.

[2]. Xiao-Yu Zhu, et al. Fenobucarb induces heart failure and cerebral hemorrhage in zebrafish. Aquat Toxicol. 2019 Apr;209:34-41.

Density 1.0±0.1 g/cm3
Boiling Point 282.5±23.0 °C at 760 mmHg
Molecular Formula C12H17NO2
Molecular Weight 207.269
Flash Point 124.7±22.6 °C
Exact Mass 207.125931
PSA 38.33000
LogP 3.04
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.505

CHEMICAL IDENTIFICATION

RTECS NUMBER :
FB5425000
CHEMICAL NAME :
Carbamic acid, methyl-, o-sec-butylphenyl ester
CAS REGISTRY NUMBER :
3766-81-2
LAST UPDATED :
199710
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C12-H17-N-O2
MOLECULAR WEIGHT :
207.30
WISWESSER LINE NOTATION :
4R BOVM1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
350 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 8,41,1983
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,371,1991
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
173 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SPEADM Special Publication of the Entomological Society of America. (4603 Calvert Rd., College Park, MD 20740) Volume(issue)/page/year: 78-1,57,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
340 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BESAAT Bulletin of the Entomological Society of America. (Entomological Soc. of America, 4603 Calvert Rd., College Park, MD 20740) V.1- 1955- Volume(issue)/page/year: 15,132,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
140 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - muscle contraction or spasticity Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 4,724,1984
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
42 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - muscle contraction or spasticity Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 4,724,1984
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - quail
DOSE/DURATION :
141 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 51,137,1996 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-JAPAN:TWA 5 mg/m3;Skin JAN 1993
Symbol GHS07 GHS09
GHS07, GHS09
Signal Word Warning
Hazard Statements H302-H410
Precautionary Statements P273-P501
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xn: Harmful;N: Dangerous for the environment;T: Toxic;F: Flammable;
Risk Phrases R22;R50/53
Safety Phrases S60-S61-S45-S24-S16-S7
RIDADR UN 2811
RTECS FB5425000
Packaging Group III
Hazard Class 6.1(b)
HS Code 2922499915
HS Code 2924199090
Summary 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%