Fenobucarb

Modify Date: 2024-01-04 21:00:51

Fenobucarb Structure
Fenobucarb structure
 Common Name Fenobucarb
CAS Number 3766-81-2 Molecular Weight 207.269
Density 1.0±0.1 g/cm3 Boiling Point 282.5±23.0 °C at 760 mmHg
Molecular Formula C12H17NO2 Melting Point N/A
MSDS Chinese USA Flash Point 124.7±22.6 °C
Symbol GHS07 GHS09
GHS07, GHS09		 Signal Word Warning

 Use of Fenobucarb


Fenobucarb is an extensively used carbamate insecticide. Fenobucarb induces zebrafish developmental neurotoxicity through pathways involved in inflammation, oxidative stress, degeneration and apoptosis. Fenobucarb is a possible risk factor to cardiovascular and cerebrovascular systems in animals[1][2].

 Names

Name fenobucarb
Synonym More Synonyms

 Fenobucarb Biological Activity

Description Fenobucarb is an extensively used carbamate insecticide. Fenobucarb induces zebrafish developmental neurotoxicity through pathways involved in inflammation, oxidative stress, degeneration and apoptosis. Fenobucarb is a possible risk factor to cardiovascular and cerebrovascular systems in animals[1][2].
Related Catalog
References

[1]. Xiao-Yu Zhu, et al. Fenobucarb-induced developmental neurotoxicity and mechanisms in zebrafish. Neurotoxicology. 2020 Jul;79:11-19.

[2]. Xiao-Yu Zhu, et al. Fenobucarb induces heart failure and cerebral hemorrhage in zebrafish. Aquat Toxicol. 2019 Apr;209:34-41.

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 282.5±23.0 °C at 760 mmHg
Molecular Formula C12H17NO2
Molecular Weight 207.269
Flash Point 124.7±22.6 °C
Exact Mass 207.125931
PSA 38.33000
LogP 3.04
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.505

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
FB5425000
CHEMICAL NAME :
Carbamic acid, methyl-, o-sec-butylphenyl ester
CAS REGISTRY NUMBER :
3766-81-2
LAST UPDATED :
199710
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C12-H17-N-O2
MOLECULAR WEIGHT :
207.30
WISWESSER LINE NOTATION :
4R BOVM1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
350 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 8,41,1983
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,371,1991
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
173 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SPEADM Special Publication of the Entomological Society of America. (4603 Calvert Rd., College Park, MD 20740) Volume(issue)/page/year: 78-1,57,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
340 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BESAAT Bulletin of the Entomological Society of America. (Entomological Soc. of America, 4603 Calvert Rd., College Park, MD 20740) V.1- 1955- Volume(issue)/page/year: 15,132,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
140 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - muscle contraction or spasticity Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 4,724,1984
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
42 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - muscle contraction or spasticity Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 4,724,1984
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - quail
DOSE/DURATION :
141 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 51,137,1996 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-JAPAN:TWA 5 mg/m3;Skin JAN 1993

 Safety Information

Symbol GHS07 GHS09
GHS07, GHS09
Signal Word Warning
Hazard Statements H302-H410
Precautionary Statements P273-P501
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xn: Harmful;N: Dangerous for the environment;T: Toxic;F: Flammable;
Risk Phrases R22;R50/53
Safety Phrases S60-S61-S45-S24-S16-S7
RIDADR UN 2811
RTECS FB5425000
Packaging Group III
Hazard Class 6.1(b)
HS Code 2922499915

 Customs

HS Code 2924199090
Summary 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Articles27

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QSAR study on permeability of hydrophobic compounds with artificial membranes.

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We previously reported a classical quantitative structure-activity relationship (QSAR) equation for permeability coefficients (P(app-pampa)) by parallel artificial membrane permeation assay (PAMPA) of...

The role of methanol addition to water samples in reducing analyte adsorption and matrix effects in liquid chromatography-tandem mass spectrometry.

J. Chromatogr. A. 1389 , 76-84, (2015)

Liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis coupled simply with water filtering before injection has proven to be a simple, economic and time-saving method for analyzing trace-l...

[Effects of rice cleaning and cooking process on the residues of flutolanil, fenobucarb, silafluofen and buprofezin in rice].

Shokuhin Eiseigaku Zasshi 44(1) , 7-12, (2003)

We studied the effect of cleaning and cooking on the residues of flutolanil, fenobucarb, silafluofen and buprofezin in rice. The rice had been sprayed in a paddy field in Wakayama city, with 3 kinds o...

 Synonyms

(RS)-2-sec-butylphenyl methylcarbamate
Fenobucarb
Phenol, 2-(1-methylpropyl)-, methylcarbamate
Carvil
EINECS 223-188-8
Fenocarb
(2-butan-2-ylphenyl) N-methylcarbamate
2-sec-Butylphenyl methylcarbamate
Bassa
2-(1-methylpropyl)phenyl methylcarbamate
Osbac
rac-2-[(2R)-butan-2-yl]phenyl methylcarbamate
Baycarb
Hopcin
O-(sec-butyl)phenyl N-methylcarbamate
fenobcarb
2-sec-butyl-phenyl N-methyl-carbamate
2-(butan-2-yl)phenyl methylcarbamate
MFCD00053081
Barizon
BPMC
2-(1-methylpropyl)phenyl N-methylcarbamate
2-(Sec-butyl)phenyl methylcarbamate
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