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94-20-2

94-20-2 structure
94-20-2 structure
  • Name: chlorpropamide
  • Chemical Name: chlorpropamide
  • CAS Number: 94-20-2
  • Molecular Formula: C10H13ClN2O3S
  • Molecular Weight: 276.740
  • Catalog: API Hormone and endocrine-regulating drugs Pancreatic hormones and other blood sugar regulating drugs
  • Create Date: 2018-09-28 09:57:27
  • Modify Date: 2026-07-03 16:53:54
  • Chlorpropamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM).Target:Chlorpropamide belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin.Chlorpropamide is not recommended for the treatment of NIDDM as it increases blood pressure and the risk of retinopathy. Up to 80% of the single oral dose of chlorpropramide is metabolized, likely in the liver; 80-90% of the dose is excreted in urine as unchanged drug and metabolites.
Name chlorpropamide
Synonyms Clorpropamide
n-Propyl-N'-p-chlorophenylsulfonylcbamide
N-[(4-Chlorophenyl)sulfonyl]-N'-propylcarbamimidic acid
Benzenesulfonamide, 4-chloro-N-[(propylamino)carbonyl]
1-p-Chlorophenyl-3-(propylsulfonyl)urea
Diabechlor
Urea, 1-[(p-chlorophenyl)sulfonyl]-3-propyl
Catanil
1-((p-chloropenyl)sulfonyl)-3-propyl-ure
Chlorodiabina
Diabinese
1-(4-Chlorophenylsulfonyl)-3-propylurea , (T)
1-(p-Chlorophenylsulfonyl)-3-propylurea
u-3818
1-Propyl-3-(p-chlorobenzenesulfonyl)urea
Adiaben
Chloropropamide
CHLORPROPRAMIDE
n-propyl-n’-p-chlorphenylsulfonylcbamide
4-chloro-N-(propylaminocarbonyl)benzenesulfonamide
4-Chloro-N-[(propylamino)-carbonyl]benzenesulfonamide
Oradian
Diabenese
CHLOROPROPAMIDE
4-Chloro-4-((propylamino)carbonyl)benzenesulfonamide
4-chloro-n-[(propylamino)carbonyl]benzenesulfonamide
P-607
Asucrol
Diabenal
n-(p-chlorobenzenesulfonyl)-n’-propylurea
1-(p-chlorobenzenesulfonyl)-3-propylure
EINECS 202-314-5
4-Chloro-N-[(propylamino)carbonyl]benzene-sul-fonamide
NCI-C01752
Dynalase
4-chloro-N-(propylcbamoyl)benzenesulfonamide
Stabinol
Diabil
MFCD00079004
Chlorpropamide
prodiaben
Chlorpropamid
1-(4-CHLOROPHENYLSULFONYL)-3-PROPYLUREA
Diabet-pages
u-9818
bioglumin
n-propyl-n’-(p-chlorobenzenesulfonyl)urea
1-(4-chlorophenyl)sulfonyl-3-propylurea
n-Propyl-N'-(p-chlorobenzenesulfonyl)urea
1-Chloro-4-(([(propylamino)carbonyl]amino)sulfonyl)benzene
4-Chloro-N-(propylcarbamoyl)benzenesulfonamide
4-chloro-n-((propylamino)carbonyl)-benzenesulfonamid
4-chloro-n-[(propylamino)carbonyl]-benzenesulfonamid
ChlorproMaMide
1-((p-chlorophenyl)sulfonyl)-3-propyl-ure
diabexan
N-(p-Chlorobenzenesulfonyl)-N'-propylurea
clorpropamida [INN_es]
1-[P-CHLOROBENZENESULFONYL]-3-PROPYLUREA
Chloronase
Diabetoral
Diamel Ex
Diabeneza
Description Chlorpropamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM).Target:Chlorpropamide belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin.Chlorpropamide is not recommended for the treatment of NIDDM as it increases blood pressure and the risk of retinopathy. Up to 80% of the single oral dose of chlorpropramide is metabolized, likely in the liver; 80-90% of the dose is excreted in urine as unchanged drug and metabolites.
Related Catalog
Density 1.4±0.1 g/cm3
Boiling Point 433.5±47.0 °C at 760 mmHg
Melting Point 128 °C
Molecular Formula C10H13ClN2O3S
Molecular Weight 276.740
Flash Point 216.0±29.3 °C
Exact Mass 276.033539
PSA 83.65000
LogP 2.80
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.585
Stability Stable. Combustible.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YS6650000
CHEMICAL NAME :
Urea, 1-((p-chlorophenyl)sulfonyl)-3-propyl-
CAS REGISTRY NUMBER :
94-20-2
BEILSTEIN REFERENCE NO. :
2218363
LAST UPDATED :
199706
DATA ITEMS CITED :
40
MOLECULAR FORMULA :
C10-H13-Cl-N2-O3-S
MOLECULAR WEIGHT :
276.76
WISWESSER LINE NOTATION :
GR DSWMVM3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
14 mg/kg
TOXIC EFFECTS :
Cardiac - pulse rate increase, without fall in BP Nutritional and Gross Metabolic - changes in potassium Nutritional and Gross Metabolic - metabolic acidosis
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
60 mg/kg
TOXIC EFFECTS :
Behavioral - coma Endocrine - hypoglycemia
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
25 mg/kg/5D-I
TOXIC EFFECTS :
Blood - other hemolysis with or without anemia
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human
DOSE/DURATION :
300 mg/kg/4W
TOXIC EFFECTS :
Blood - granulocytopenia Blood - leukopenia Nutritional and Gross Metabolic - body temperature increase
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
83 mg/kg/25D-I
TOXIC EFFECTS :
Gastrointestinal - ulceration or bleeding from large intestine Liver - jaundice, cholestatic
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
580 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
590 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
409 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
1039 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
884 mg/kg
SEX/DURATION :
female 1-35 week(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
840 mg/kg
SEX/DURATION :
female 9-39 week(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - Apgar score (human only)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
240 mg/kg
SEX/DURATION :
female 32-38 week(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
DOSE :
1358 mg/kg
SEX/DURATION :
female 1-26 week(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - stillbirth
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
DOSE :
180 mg/kg
SEX/DURATION :
female 26-39 week(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
DOSE :
450 mg/kg
SEX/DURATION :
female 26-39 week(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - stillbirth
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1 gm/kg
SEX/DURATION :
female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
12 gm/kg
SEX/DURATION :
female 1-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - abortion Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
1800 mg/kg
SEX/DURATION :
female 9-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
DOSE :
45 mg/kg
SEX/DURATION :
female 1-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
TYPE OF TEST :
Sister chromatid exchange
TYPE OF TEST :
Sister chromatid exchange
TYPE OF TEST :
Micronucleus test
TYPE OF TEST :
Sister chromatid exchange

MUTATION DATA

TEST SYSTEM :
Rodent - hamster
DOSE/DURATION :
7100 ug/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 77,349,1980 *** REVIEWS *** TOXICOLOGY REVIEW KDYIA5 Kidney International. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus Secaucus, NJ 07094) V.1- 1972- Volume(issue)/page/year: 10,82,1976 TOXICOLOGY REVIEW CLPTAT Clinical Pharmacology and Therapeutics (St. Louis). (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1960- Volume(issue)/page/year: 5,480,1964 TOXICOLOGY REVIEW ARVPAX Annual Review of Pharmacology. (Palo Alto, CA) V.1-15, 1961-75. For publisher information, see ARPTDI. Volume(issue)/page/year: 5,447,1965 TOXICOLOGY REVIEW BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 1,59,1963 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3997 No. of Facilities: 35 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 311 (estimated) No. of Female Employees: 198 (estimated)
Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Warning
Hazard Statements H312-H332-H351
Precautionary Statements P280
Personal Protective Equipment Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes Xn: Harmful;
Risk Phrases R20/21/22
Safety Phrases S22-S36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS YS6650000
HS Code 2935009090
110-78-1 structure

110-78-1

98-64-6 structure

98-64-6

~92%

94-20-2 structure

94-20-2

Literature: Tan, Davin; Strukil, Vjekoslav; Mottillo, Cristina; Friscic, Tomislav Chemical Communications, 2014 , vol. 50, # 40 p. 5248 - 5250
98-64-6 structure

98-64-6

39078-44-9 structure

39078-44-9

~76%

94-20-2 structure

94-20-2

Literature: Mizuno, Takumi; Kino, Takanobu; Ito, Takatoshi; Miyata, Toshiyuki Synthetic Communications, 2000 , vol. 30, # 17 p. 3081 - 3089
96-49-1 structure

96-49-1

98-64-6 structure

98-64-6

~%

94-20-2 structure

94-20-2

Literature: US4062889 A1, ;
HS Code 2935009090
Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%
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