chlorpropamide

Modify Date: 2026-07-03 16:53:54

chlorpropamide Structure
chlorpropamide structure
 Common Name chlorpropamide
CAS Number 94-20-2 Molecular Weight 276.740
Density 1.4±0.1 g/cm3 Boiling Point 433.5±47.0 °C at 760 mmHg
Molecular Formula C10H13ClN2O3S Melting Point 128 °C
MSDS Chinese USA Flash Point 216.0±29.3 °C
Symbol GHS07 GHS08
GHS07, GHS08		 Signal Word Warning

 Use of chlorpropamide


Chlorpropamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM).Target:Chlorpropamide belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin.Chlorpropamide is not recommended for the treatment of NIDDM as it increases blood pressure and the risk of retinopathy. Up to 80% of the single oral dose of chlorpropramide is metabolized, likely in the liver; 80-90% of the dose is excreted in urine as unchanged drug and metabolites.

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name chlorpropamide
Synonym More Synonyms

 chlorpropamide Biological Activity

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description Chlorpropamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM).Target:Chlorpropamide belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin.Chlorpropamide is not recommended for the treatment of NIDDM as it increases blood pressure and the risk of retinopathy. Up to 80% of the single oral dose of chlorpropramide is metabolized, likely in the liver; 80-90% of the dose is excreted in urine as unchanged drug and metabolites.
Related Catalog

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 1.4±0.1 g/cm3
Boiling Point 433.5±47.0 °C at 760 mmHg
Melting Point 128 °C
Molecular Formula C10H13ClN2O3S
Molecular Weight 276.740
Flash Point 216.0±29.3 °C
Exact Mass 276.033539
PSA 83.65000
LogP 2.80
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.585
InChIKey RKWGIWYCVPQPMF-UHFFFAOYSA-N
SMILES CCCNC(=O)NS(=O)(=O)c1ccc(Cl)cc1
Stability Stable. Combustible.

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

 Toxicological Information

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YS6650000
CHEMICAL NAME :
Urea, 1-((p-chlorophenyl)sulfonyl)-3-propyl-
CAS REGISTRY NUMBER :
94-20-2
BEILSTEIN REFERENCE NO. :
2218363
LAST UPDATED :
199706
DATA ITEMS CITED :
40
MOLECULAR FORMULA :
C10-H13-Cl-N2-O3-S
MOLECULAR WEIGHT :
276.76
WISWESSER LINE NOTATION :
GR DSWMVM3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
14 mg/kg
TOXIC EFFECTS :
Cardiac - pulse rate increase, without fall in BP Nutritional and Gross Metabolic - changes in potassium Nutritional and Gross Metabolic - metabolic acidosis
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
60 mg/kg
TOXIC EFFECTS :
Behavioral - coma Endocrine - hypoglycemia
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
25 mg/kg/5D-I
TOXIC EFFECTS :
Blood - other hemolysis with or without anemia
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human
DOSE/DURATION :
300 mg/kg/4W
TOXIC EFFECTS :
Blood - granulocytopenia Blood - leukopenia Nutritional and Gross Metabolic - body temperature increase
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
83 mg/kg/25D-I
TOXIC EFFECTS :
Gastrointestinal - ulceration or bleeding from large intestine Liver - jaundice, cholestatic
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
580 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
590 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
409 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
1039 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
884 mg/kg
SEX/DURATION :
female 1-35 week(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
840 mg/kg
SEX/DURATION :
female 9-39 week(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - Apgar score (human only)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
240 mg/kg
SEX/DURATION :
female 32-38 week(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
DOSE :
1358 mg/kg
SEX/DURATION :
female 1-26 week(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - stillbirth
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
DOSE :
180 mg/kg
SEX/DURATION :
female 26-39 week(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
DOSE :
450 mg/kg
SEX/DURATION :
female 26-39 week(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - stillbirth
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1 gm/kg
SEX/DURATION :
female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
12 gm/kg
SEX/DURATION :
female 1-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - abortion Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
1800 mg/kg
SEX/DURATION :
female 9-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
DOSE :
45 mg/kg
SEX/DURATION :
female 1-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
TYPE OF TEST :
Sister chromatid exchange
TYPE OF TEST :
Sister chromatid exchange
TYPE OF TEST :
Micronucleus test
TYPE OF TEST :
Sister chromatid exchange

MUTATION DATA

TEST SYSTEM :
Rodent - hamster
DOSE/DURATION :
7100 ug/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 77,349,1980 *** REVIEWS *** TOXICOLOGY REVIEW KDYIA5 Kidney International. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus Secaucus, NJ 07094) V.1- 1972- Volume(issue)/page/year: 10,82,1976 TOXICOLOGY REVIEW CLPTAT Clinical Pharmacology and Therapeutics (St. Louis). (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1960- Volume(issue)/page/year: 5,480,1964 TOXICOLOGY REVIEW ARVPAX Annual Review of Pharmacology. (Palo Alto, CA) V.1-15, 1961-75. For publisher information, see ARPTDI. Volume(issue)/page/year: 5,447,1965 TOXICOLOGY REVIEW BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 1,59,1963 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3997 No. of Facilities: 35 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 311 (estimated) No. of Female Employees: 198 (estimated)

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Warning
Hazard Statements H312-H332-H351
Precautionary Statements P280
Personal Protective Equipment Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes Xn: Harmful;
Risk Phrases R20/21/22
Safety Phrases S22-S36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS YS6650000
HS Code 2935009090

 Synthetic Route

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

1-Isocyanato propane structure

1-Isocyanato propane

CAS#:110-78-1

4-Chlorobenzenesulfonamide structure

4-Chlorobenzene...

CAS#:98-64-6

~92%

chlorpropamide Structure

chlorpropamide

CAS#:94-20-2

Learn More
Literature: Tan, Davin; Strukil, Vjekoslav; Mottillo, Cristina; Friscic, Tomislav Chemical Communications, 2014 , vol. 50, # 40 p. 5248 - 5250
4-Chlorobenzenesulfonamide structure

4-Chlorobenzene...

CAS#:98-64-6

S-Methyl N-propyl(thiocarbamate) structure

S-Methyl N-prop...

CAS#:39078-44-9

~76%

chlorpropamide Structure

chlorpropamide

CAS#:94-20-2

Learn More
Literature: Mizuno, Takumi; Kino, Takanobu; Ito, Takatoshi; Miyata, Toshiyuki Synthetic Communications, 2000 , vol. 30, # 17 p. 3081 - 3089
Ethylene carbonate structure

Ethylene carbonate

CAS#:96-49-1

4-Chlorobenzenesulfonamide structure

4-Chlorobenzene...

CAS#:98-64-6

~%

chlorpropamide Structure

chlorpropamide

CAS#:94-20-2

Learn More
Literature: US4062889 A1, ;

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2935009090
Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

 Articles47

More Articles

This table lists relevant public references with title, journal and publication metadata for this compound.

Sulfa drugs inhibit sepiapterin reduction and chemical redox cycling by sepiapterin reductase.

J. Pharmacol. Exp. Ther. 352(3) , 529-40, (2015)

Sepiapterin reductase (SPR) catalyzes the reduction of sepiapterin to dihydrobiopterin (BH2), the precursor for tetrahydrobiopterin (BH4), a cofactor critical for nitric oxide biosynthesis and alkylgl...

Evaluation of the in vitro/in vivo potential of five berries (bilberry, blueberry, cranberry, elderberry, and raspberry ketones) commonly used as herbal supplements to inhibit uridine diphospho-glucuronosyltransferase.

Food Chem. Toxicol. 72 , 13-9, (2014)

In this study, we evaluated inhibitory potentials of popularly-consumed berries (bilberry, blueberry, cranberry, elderberry, and raspberry ketones) as herbal supplements on UGT1A1, UGT1A4, UGT1A6, UGT...

Evaluation of thein vitro/in vivodrug interaction potential of BST204, a purified dry extract of ginseng, and its four bioactive ginsenosides through cytochrome P450 inhibition/induction and UDP-glucuronosyltransferase inhibition

Food Chem. Toxicol. 68 , 117-27, (2014)

• BST204 is a purified dry extract of ginseng containing high amounts of Rh2 and Rg3. • BST204 had only weak inhibitory effects on nine CYPs and five UGTs. • It is unlikely that BST204 alter pharmacok...

 chlorpropamideBioassay

View more

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase
Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273
Name: Partition coefficient (logD6.5)
Source: ChEMBL
Target: N/A
External Id: CHEMBL646647
Name: Increase the activity of the Burkholderia fixLJ 2-component system
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: Burkholderia multivorans
External Id: HMS1625
Name: Drug activation in human Hep3B cells assessed as human CYP2C9-mediated drug metabolis...
Source: ChEMBL
Target: Cytochrome P450 2C9
External Id: CHEMBL4478999
Name: Drug activation in human Hep3B cells assessed as human CYP3A4-mediated drug metabolis...
Source: ChEMBL
Target: Cytochrome P450 3A4
External Id: CHEMBL4479000
Name: Drug activation in human Hep3B cells assessed as human CYP2D6-mediated drug metabolis...
Source: ChEMBL
Target: Cytochrome P450 2D6
External Id: CHEMBL4479083
Name: Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV)
Source: NCGC
External Id: APP-Toga-CHIKV-nsp2-p
Name: qHTS assay to identify small molecule antagonists of the estrogen related receptor (E...
Source: 824
Target: N/A
External Id: ERR513
Name: qHTS assay to identify small molecule antagonists of the estrogen related receptor (E...
Source: 824
External Id: ERR845
Total 854, Current Page 1 of 86
1
2
3
4
5

 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

Chloropropamide
chlorpropamide
EINECS 202-314-5
4-chloro-N-(propylaminocarbonyl)benzenesulfonamide
N-[(4-Chlorophenyl)sulfonyl]-N'-propylcarbamimidic acid
MFCD00079004
clorpropamida [INN_es]
1-(4-chlorophenyl)sulfonyl-3-propylurea
4-Chloro-N-(propylcarbamoyl)benzenesulfonamide

 chlorpropamide | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the molecular formula of chlorpropamide?
A: Molecular formula of chlorpropamide is C10H13ClN2O3S.
Q: What is the safety information for chlorpropamide?
A: Safety information for chlorpropamide: S22-S36.
Q: What is the InChIKey of chlorpropamide?
A: InChIKey of chlorpropamide is RKWGIWYCVPQPMF-UHFFFAOYSA-N.
Q: What are the downstream products of chlorpropamide?
A: Related downstream products(CAS) of chlorpropamide: 98-64-6;627-06-5;623-12-1;2050-68-2;108-90-7;2051-62-9;71-43-2;5769-15-3.
Q: What is the CAS number of chlorpropamide?
A: CAS number of chlorpropamide is 94-20-2.
Q: What is the SMILES notation of chlorpropamide?
A: SMILES notation of chlorpropamide is CCCNC(=O)NS(=O)(=O)c1ccc(Cl)cc1.
Q: What are the upstream materials of chlorpropamide?
A: Related upstream materials(CAS) of chlorpropamide: 110-78-1;98-64-6;39078-44-9;96-49-1.
Q: What is the English name of chlorpropamide?
A: The English name of chlorpropamide is chlorpropamide.
Q: What is the LogP of chlorpropamide?
A: LogP of chlorpropamide is 2.80.
Q: What is the boiling point of chlorpropamide?
A: Boiling point of chlorpropamide is 433.5±47.0 °C at 760 mmHg.

 chlorpropamidefactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
Dayang Chem (Hangzhou) Co., Ltd.
Henan Tianfu Chemical Co., Ltd.
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Chemsrc provides chlorpropamide(CAS#:94-20-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of chlorpropamide are included as well.>> amp version: chlorpropamide

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