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69049-73-6

69049-73-6 structure
69049-73-6 structure
  • Name: Nedocromil
  • Chemical Name: nedocromil
  • CAS Number: 69049-73-6
  • Molecular Formula: C19H17NO7
  • Molecular Weight: 371.341
  • Catalog: API Respiratory medication Asthma
  • Create Date: 2018-02-25 08:00:00
  • Modify Date: 2024-01-03 18:09:27
  • Nedocromil suppresses the action or formation of multiple mediators, including histamine, leukotriene C4 (LTC4), and prostaglandin D2 (PGD2).

Name nedocromil
Synonyms Nedocromil
Nedocromilum
9-Ethyl-4,6-dioxo-10-propyl-6,9-dihydro-4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid
FPL 59002KP
4H-Pyrano[3,2-g]quinoline-2,8-dicarboxylic acid, 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-
9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4H-pyrano(3,2-g)quinoline-2,8-dicarboxylic acid
Nedocromilo [Spanish]
Nedocromilum [Latin]
Tilade
Nedocromilo
9-ethyl-4,6-dioxo-10-propylpyrano[3,2-g]quinoline-2,8-dicarboxylic acid
4,6-Dioxo-1-ethyl-10-propyl-4H,6H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid
Nedocromil [USAN:BAN:INN]
Alocril
Description Nedocromil suppresses the action or formation of multiple mediators, including histamine, leukotriene C4 (LTC4), and prostaglandin D2 (PGD2).
Related Catalog
Target

Histamine

LTC4

PGD2

In Vitro Nedocromil inhibits the release of histamine, LTC4, and PGD2 from mast cells challenged with antigen (with IC30 values of 2.1 μM, 2.3 μM, and 1.9 μM, respectively) and with anti-human IgE (IC30 values of 4.7 μM, 1.3 μM, and 1.3 μM, respectively)[1].
In Vivo Nedocromil-treated diabetic mice show significantly improved heart function compared with controls. The contractility and relaxation forces show similar improvements. However, the cardiac function of Nedocromil-treated diabetic mice remains significantly impaired when compared with normal mice. Nedocromil can significantly improve cardiac function in mice with diabetic cardiomyopathy, but the treatment cannot restore normal function[2].
Animal Admin Mice[2] 8-12 weeks old C57/BL6 male mice between 23-25 g receive intraperitoneal (i.p.) injections of 50 mg/kg Streptozotocin (STZ), dissolved in 100 mM citrate buffer pH 4.5, for five consecutive days. Diabetic mice (13-week-old) are randomly divided into three groups: 1) untreated group; 2) Nedocromil group, with Nedocromil released at the rate of 30 mg/kg per day from a subcutaneous (s.c.) pellet implantation; and vehicle group, with an inactive pellet implanted. Normal mice (non-diabetic) and normal mice that receive Nedocromil (30 mg/kg per day) are also included in this study for comparison. All sample groups included 15 mice (n=15)[2].
References

[1]. Wells E, et al. Characterization of primate bronchoalveolar mast cells. II. Inhibition of histamine, LTC4, and PGD2 release from primate bronchoalveolar mast cells and a comparison with rat peritoneal mastcells. J Immunol. 1986 Dec 15;137(12):3941-5.

[2]. Myocardial remodeling in diabetic cardiomyopathy associated with cardiac mast cell activation. Huang ZG, et al. PLoS One. 2013;8(3):e60827.

Density 1.5±0.1 g/cm3
Boiling Point 645.5±55.0 °C at 760 mmHg
Melting Point 299ºC
Molecular Formula C19H17NO7
Molecular Weight 371.341
Flash Point 344.2±31.5 °C
Exact Mass 371.100494
PSA 126.81000
LogP 2.52
Appearance white to beige
Vapour Pressure 0.0±2.0 mmHg at 25°C
Index of Refraction 1.641
Storage condition 2-8°C
Water Solubility DMSO: soluble2mg/mL, clear (warmed)
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H319
Precautionary Statements P305 + P351 + P338
Hazard Codes Xi
Risk Phrases 36
Safety Phrases 26
RIDADR NONH for all modes of transport