844-26-8

844-26-8 structure

Name: Bithionol (sulfoxide)
Chemical Name: 2,4-dichloro-6-(3,5-dichloro-2-hydroxyphenyl)sulfinylphenol
CAS Number: 844-26-8
Molecular Formula: C₁₂H₆Cl₄O₃S
Molecular Weight: 372.05100
Catalog: Signaling Pathways Anti-infection Parasite
Create Date: 2018-09-07 14:26:31
Modify Date: 2024-01-02 09:12:33
Bithionol sulfoxide(Bitin-S) is a clinically approved anti-parasitic drug; has been shown to inhibit solid tumor growth in several preclinical cancer models.IC50 value:Target: anticaner agentBithionol caused dose dependent cytotoxicity against all ovarian cancer cell lines tested with IC50 values ranging from 19 μM - 60 μM. BT treatment resulted in cell cycle arrest at G1/M phase and increased ROS generation [1]. Both bithionol and bithionol sulphoxide demonstrated in vitro toxicity to Neoparamoeba spp. at all concentrations examined (0.1 to 10 mg l(-1) over 72 h), with a comparable toxicity to freshwater observed for both chemicals at concentrations > 5 mg l(-1) following a 72 h treatment [2].

Name	2,4-dichloro-6-(3,5-dichloro-2-hydroxyphenyl)sulfinylphenol
Synonyms	Sulphene bithionol sulfoxide Bithionoloxide 4,6,4',6'-tetrachloro-2,2'-sulfinyl-di-phenol Disto-5-cogla Bitionoloxido [Spanish] Bithionoloxide [INN] 2,2'-sulfinyl-bis(4,6-dichlorophenol) Bitin S Distobitin Bis-(3,5-dichlor-2-hydroxyphenyl)sulfoxid Bis-(3.5-dichlor-2-hydroxy-phenyl)-sulfoxyd Bithionoloxidum [Latin] 4,6,4',6'-Tetrachlor-2,2'-sulfinyl-di-phenol Bithionol (sulfoxide)

Description	Bithionol sulfoxide(Bitin-S) is a clinically approved anti-parasitic drug; has been shown to inhibit solid tumor growth in several preclinical cancer models.IC50 value:Target: anticaner agentBithionol caused dose dependent cytotoxicity against all ovarian cancer cell lines tested with IC50 values ranging from 19 μM - 60 μM. BT treatment resulted in cell cycle arrest at G1/M phase and increased ROS generation [1]. Both bithionol and bithionol sulphoxide demonstrated in vitro toxicity to Neoparamoeba spp. at all concentrations examined (0.1 to 10 mg l(-1) over 72 h), with a comparable toxicity to freshwater observed for both chemicals at concentrations > 5 mg l(-1) following a 72 h treatment [2].
Related Catalog	Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Cancer
References	[1]. Ayyagari VN, et al. Bithionol inhibits ovarian cancer cell growth in vitro - studies on mechanism(s) of action. BMC Cancer. 2014 Feb 4;14:61. [2]. Florent RL, et al. In vitro toxicity of bithionol and bithionol sulphoxide to Neoparamoeba spp., the causative agent of amoebic gill disease (AGD). Dis Aquat Organ. 2010 Sep 17;91(3):257-62.

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 188,53,1987

HS Code	2930909090

120-83-2

844-26-8

Literature: Journal of the American Chemical Society, , vol. 67, p. 238

97-18-7

844-26-8

Literature: Yakugaku Zasshi, , vol. 78, p. 482,485 Chem.Abstr., , p. 17267

861011-20-3

844-26-8

Literature: Yakugaku Zasshi, , vol. 78, p. 482,485 Chem.Abstr., , p. 17267

57548-01-3

844-26-8

Literature: Yakugaku Zasshi, , vol. 78, p. 482,485 Chem.Abstr., , p. 17267

HS Code	2930909090
Summary	2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%