Bithionol (sulfoxide)
Modify Date: 2024-01-02 09:12:33
Bithionol (sulfoxide) structure
|
Common Name | Bithionol (sulfoxide) | ||
|---|---|---|---|---|
| CAS Number | 844-26-8 | Molecular Weight | 372.05100 | |
| Density | 1.86 g/cm3 | Boiling Point | 532.7ºC at 760 mmHg | |
| Molecular Formula | C12H6Cl4O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 276ºC | |
Use of Bithionol (sulfoxide)Bithionol sulfoxide(Bitin-S) is a clinically approved anti-parasitic drug; has been shown to inhibit solid tumor growth in several preclinical cancer models.IC50 value:Target: anticaner agentBithionol caused dose dependent cytotoxicity against all ovarian cancer cell lines tested with IC50 values ranging from 19 μM - 60 μM. BT treatment resulted in cell cycle arrest at G1/M phase and increased ROS generation [1]. Both bithionol and bithionol sulphoxide demonstrated in vitro toxicity to Neoparamoeba spp. at all concentrations examined (0.1 to 10 mg l(-1) over 72 h), with a comparable toxicity to freshwater observed for both chemicals at concentrations > 5 mg l(-1) following a 72 h treatment [2]. |
| Name | 2,4-dichloro-6-(3,5-dichloro-2-hydroxyphenyl)sulfinylphenol |
|---|---|
| Synonym | More Synonyms |
| Description | Bithionol sulfoxide(Bitin-S) is a clinically approved anti-parasitic drug; has been shown to inhibit solid tumor growth in several preclinical cancer models.IC50 value:Target: anticaner agentBithionol caused dose dependent cytotoxicity against all ovarian cancer cell lines tested with IC50 values ranging from 19 μM - 60 μM. BT treatment resulted in cell cycle arrest at G1/M phase and increased ROS generation [1]. Both bithionol and bithionol sulphoxide demonstrated in vitro toxicity to Neoparamoeba spp. at all concentrations examined (0.1 to 10 mg l(-1) over 72 h), with a comparable toxicity to freshwater observed for both chemicals at concentrations > 5 mg l(-1) following a 72 h treatment [2]. |
|---|---|
| Related Catalog | |
| References |
| Density | 1.86 g/cm3 |
|---|---|
| Boiling Point | 532.7ºC at 760 mmHg |
| Molecular Formula | C12H6Cl4O3S |
| Molecular Weight | 372.05100 |
| Flash Point | 276ºC |
| Exact Mass | 369.87900 |
| PSA | 76.74000 |
| LogP | 5.74380 |
| Index of Refraction | 1.769 |
| Storage condition | 2-8℃ |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
|
| HS Code | 2930909090 |
|---|
|
~%
Bithionol (sulf... CAS#:844-26-8 |
| Literature: Journal of the American Chemical Society, , vol. 67, p. 238 |
|
~%
Bithionol (sulf... CAS#:844-26-8 |
| Literature: Yakugaku Zasshi, , vol. 78, p. 482,485 Chem.Abstr., , p. 17267 |
|
~%
Bithionol (sulf... CAS#:844-26-8 |
| Literature: Yakugaku Zasshi, , vol. 78, p. 482,485 Chem.Abstr., , p. 17267 |
|
~%
Bithionol (sulf... CAS#:844-26-8 |
| Literature: Yakugaku Zasshi, , vol. 78, p. 482,485 Chem.Abstr., , p. 17267 |
CAS#:4568-36-9| HS Code | 2930909090 |
|---|---|
| Summary | 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
| Sulphene |
| bithionol sulfoxide |
| Bithionoloxide |
| 4,6,4',6'-tetrachloro-2,2'-sulfinyl-di-phenol |
| Disto-5-cogla |
| Bitionoloxido [Spanish] |
| Bithionoloxide [INN] |
| 2,2'-sulfinyl-bis(4,6-dichlorophenol) |
| Bitin S |
| Distobitin |
| Bis-(3,5-dichlor-2-hydroxyphenyl)sulfoxid |
| Bis-(3.5-dichlor-2-hydroxy-phenyl)-sulfoxyd |
| Bithionoloxidum [Latin] |
| 4,6,4',6'-Tetrachlor-2,2'-sulfinyl-di-phenol |
| Bithionol (sulfoxide) |