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97-18-7

97-18-7 structure
97-18-7 structure
  • Name: Bithionol
  • Chemical Name: bithionol
  • CAS Number: 97-18-7
  • Molecular Formula: C12H6Cl4O2S
  • Molecular Weight: 356.052
  • Catalog: Organic raw materials Organic fluorine compound Fluoroethane series
  • Create Date: 2018-02-14 08:00:00
  • Modify Date: 2024-01-03 01:10:13
  • Bithionol is a clinically approved anti-parasitic drug; has been shown to inhibit solid tumor growth in several preclinical cancer models.IC50 value:Target: anticaner agentBithionol caused dose dependent cytotoxicity against all ovarian cancer cell lines tested with IC50 values ranging from 19 μM - 60 μM. BT treatment resulted in cell cycle arrest at G1/M phase and increased ROS generation [1]. Both bithionol and bithionol sulphoxide demonstrated in vitro toxicity to Neoparamoeba spp. at all concentrations examined (0.1 to 10 mg l(-1) over 72 h), with a comparable toxicity to freshwater observed for both chemicals at concentrations > 5 mg l(-1) following a 72 h treatment [2].
Name bithionol
Synonyms Phenol, 2,2'-thiobis(4,6-dichloro)-
Phenol, 2,2'-thiobis[4,6-dichloro-
Bitin
2-Hydroxy-3,5-dichlorophenyl sulfide
Bithionolate
2,2'-Thiobis[4,6-dichlorophenol]
2,2-DIMETHYL-7-ETHOXY-6-METHOXY-4-CHROMANONE
MFCD00055727
2,2'-Sulfanediylbis(4,6-dichlorophenol)
Bidiphen
2,2'-Thiobis- (4,6-dichlorophenol)
2,2’-thiobis[4,6-dichlorophenol]
Bithionol sulfide
Bithin
EINECS 202-565-0
2,2'-Thio-bis(4,6-dichlorophenol)
2,2'-Thiobis(4,6-dichlorophenol)
Bithionol
2,2'-Sulfanediylbis(4,6-dichlorphenol)
2,2’-sulfanediylbis(4,6-dichlorophenol)
Bitionol
Bis(2-hydroxy-3,5-dichlorophenyl)sulfide
2-Hydroxy-3,5-dichlorophenyl sulphide
2,4-dichloro-6-(3,5-dichloro-2-hydroxyphenyl)sulfanylphenol
bis (2-hydroxy-3,5-dichlorophenyl)-sulphide
bis(3,5-dichloro-2-hydroxy phenyl)-sulfide
Phenol, 2,2'-thiobis 4,6-dichloro-
2,2’-thiobis(4,6-dichlorophenol)
Lorothidol
Actamer
Description Bithionol is a clinically approved anti-parasitic drug; has been shown to inhibit solid tumor growth in several preclinical cancer models.IC50 value:Target: anticaner agentBithionol caused dose dependent cytotoxicity against all ovarian cancer cell lines tested with IC50 values ranging from 19 μM - 60 μM. BT treatment resulted in cell cycle arrest at G1/M phase and increased ROS generation [1]. Both bithionol and bithionol sulphoxide demonstrated in vitro toxicity to Neoparamoeba spp. at all concentrations examined (0.1 to 10 mg l(-1) over 72 h), with a comparable toxicity to freshwater observed for both chemicals at concentrations > 5 mg l(-1) following a 72 h treatment [2].
Related Catalog
References

[1]. Ayyagari VN, et al. Bithionol inhibits ovarian cancer cell growth in vitro - studies on mechanism(s) of action. BMC Cancer. 2014 Feb 4;14:61.

[2]. Florent RL, et al. In vitro toxicity of bithionol and bithionol sulphoxide to Neoparamoeba spp., the causative agent of amoebic gill disease (AGD). Dis Aquat Organ. 2010 Sep 17;91(3):257-62.
Density 1.8±0.1 g/cm3
Boiling Point 444.7±45.0 °C at 760 mmHg
Melting Point 188°C
Molecular Formula C12H6Cl4O2S
Molecular Weight 356.052
Flash Point 222.8±28.7 °C
Exact Mass 353.884247
PSA 65.76000
LogP 5.51
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.741
Storage condition 0-6°C
Stability Stable. Incompatible with strong oxidizing agents.
Water Solubility <0.1 g/100 mL at 23 ºC

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SN0525000
CHEMICAL NAME :
Phenol, 2,2'-thiobis(4,6-dichloro-
CAS REGISTRY NUMBER :
97-18-7
BEILSTEIN REFERENCE NO. :
2003535
LAST UPDATED :
199710
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C12-H6-Cl4-O2-S
MOLECULAR WEIGHT :
356.04
WISWESSER LINE NOTATION :
QR BG DG FSR BQ CG EG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
760 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,612,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
18 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#01763 ** TUMORIGENIC DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
12 gm/kg/78W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - tumors
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB223-159
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Precautionary Statements P301 + P312 + P330
Personal Protective Equipment Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes Xn: Harmful;
Risk Phrases R20/21/22
Safety Phrases S28-S36/37-S45-S36
RIDADR UN 2811 6.1/PG 2
WGK Germany 3
RTECS SN0525000
Packaging Group II
Hazard Class 6.1(a)
HS Code 2930909090
120-83-2 structure

120-83-2

~%

97-18-7 structure

97-18-7

Literature: DE583055 , ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 20, p. 426
75-15-0 structure

75-15-0

7446-70-0 structure

7446-70-0

120-83-2 structure

120-83-2

~%

97-18-7 structure

97-18-7

Literature: DE583055 , ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 20, p. 426
56-23-5 structure

56-23-5

7446-70-0 structure

7446-70-0

120-83-2 structure

120-83-2

~%

97-18-7 structure

97-18-7

Literature: DE583055 , ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 20, p. 426
Total: 1 Page
HS Code 2930909090
Summary 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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title: CAS No. 97-18-7 | Chemsrc address: https://m.chemsrc.com/en/baike/752227.html

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