53411-70-4

53411-70-4 structure

Name: Trisodium 6-O-phosphonato-D-gluconate
Chemical Name: 6-Phosphogluconic acid trisodium salt
CAS Number: 53411-70-4
Molecular Formula: C₆H₁₀Na₃O₁₀P
Molecular Weight: 342.081
Catalog: Research Areas Metabolic Disease
Create Date: 2018-03-07 08:00:00
Modify Date: 2024-01-09 19:46:47
6-Phosphogluconic acid trisodium is a potent and competitive phosphoglucose isomerase (PGI) inhibitor with Kis of 48 μM for glucose 6-phosphate and 42 μM for fructose 6-phosphate. 6-Phosphogluconic acid trisodium is an endogenous metabolite[1][2].

Name	6-Phosphogluconic acid trisodium salt
Synonyms	D-Gluconic acid, 6-(dihydrogen phosphate), sodium salt (1:3) Trisodium 6-O-phosphonato-D-gluconate 6-phosphogluconic acid trisodium salt MFCD00083681 EINECS 258-543-6

Description	6-Phosphogluconic acid trisodium is a potent and competitive phosphoglucose isomerase (PGI) inhibitor with Kis of 48 μM for glucose 6-phosphate and 42 μM for fructose 6-phosphate. 6-Phosphogluconic acid trisodium is an endogenous metabolite[1][2].
Related Catalog	Research Areas >> Metabolic Disease
Target	phosphoglucose isomerase[1]
In Vitro	6-Phosphogluconic acid trisodium (0.5-2.0 mM) completely inhibits the activity of PGI with glucose 6-phosphate (0.05- 0.5 mM) as the substrate[1].
References	[1]. Gaitonde MK, et al. Effect of 6-phosphogluconate on phosphoglucose isomerase in rat brain in vitro and in vivo. J Neurochem. 1989 May;52(5):1348-52. [2]. Hitosugi T, et al. Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell. 2012 Nov 13;22(5):585-600.

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RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2931900090

HS Code	2931900090
Summary	2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%