Trisodium 6-O-phosphonato-D-gluconate

Modify Date: 2025-08-24 13:44:11

Trisodium 6-O-phosphonato-D-gluconate Structure
Trisodium 6-O-phosphonato-D-gluconate structure
 Common Name Trisodium 6-O-phosphonato-D-gluconate
CAS Number 53411-70-4 Molecular Weight 342.081
Density N/A Boiling Point N/A
Molecular Formula C6H10Na3O10P Melting Point N/A
MSDS USA Flash Point N/A

 Use of Trisodium 6-O-phosphonato-D-gluconate


6-Phosphogluconic acid trisodium is a potent and competitive phosphoglucose isomerase (PGI) inhibitor with Kis of 48 μM for glucose 6-phosphate and 42 μM for fructose 6-phosphate. 6-Phosphogluconic acid trisodium is an endogenous metabolite[1][2].

 Names

Name 6-Phosphogluconic acid trisodium salt
Synonym More Synonyms

 Trisodium 6-O-phosphonato-D-gluconate Biological Activity

Description 6-Phosphogluconic acid trisodium is a potent and competitive phosphoglucose isomerase (PGI) inhibitor with Kis of 48 μM for glucose 6-phosphate and 42 μM for fructose 6-phosphate. 6-Phosphogluconic acid trisodium is an endogenous metabolite[1][2].
Related Catalog
Target

phosphoglucose isomerase[1]

In Vitro 6-Phosphogluconic acid trisodium (0.5-2.0 mM) completely inhibits the activity of PGI with glucose 6-phosphate (0.05- 0.5 mM) as the substrate[1].
References

[1]. Gaitonde MK, et al. Effect of 6-phosphogluconate on phosphoglucose isomerase in rat brain in vitro and in vivo. J Neurochem. 1989 May;52(5):1348-52.

[2]. Hitosugi T, et al. Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell. 2012 Nov 13;22(5):585-600.

 Chemical & Physical Properties

Molecular Formula C6H10Na3O10P
Molecular Weight 342.081
Exact Mass 341.970459
PSA 203.28000
Storage condition −20°C
Water Solubility H2O: 50 mg/mL, clear, colorless

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2931900090

 Customs

HS Code 2931900090
Summary 2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

 Synonyms

D-Gluconic acid, 6-(dihydrogen phosphate), sodium salt (1:3)
Trisodium 6-O-phosphonato-D-gluconate
6-phosphogluconic acid trisodium salt
MFCD00083681
EINECS 258-543-6
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Chemsrc provides Trisodium 6-O-phosphonato-D-gluconate(CAS#:53411-70-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Trisodium 6-O-phosphonato-D-gluconate are included as well.>> amp version: Trisodium 6-O-phosphonato-D-gluconate

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