80288-49-9
80288-49-9 structure
- Name: Furafylline
- Chemical Name: 3-(furan-2-ylmethyl)-1,8-dimethyl-7H-purine-2,6-dione
- CAS Number: 80288-49-9
- Molecular Formula: C12H12N4O3
- Molecular Weight: 260.249
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Cytochrome P450
- Create Date: 2018-08-12 20:43:29
- Modify Date: 2025-09-10 09:40:38
-
Furafylline is a potent and selective inhibitor of human cytochrome P450IA2 with an IC50 of 0.07 μM.
| Name | 3-(furan-2-ylmethyl)-1,8-dimethyl-7H-purine-2,6-dione |
|---|---|
| Synonyms |
1H-Purine-2,6-dione, 3-(2-furanylmethyl)-3,7-dihydro-1,8-dimethyl-
3-(2-Furylmethyl)-1,8-dimethyl-3,7-dihydro-1H-purine-2,6-dione furafylline 3-Furfuryl-1,8-dimethylxanthine 3-(furan-2-ylmethyl)-1,8-dimethyl-3,7-dihydro-1H-purine-2,6-dione |
| Description | Furafylline is a potent and selective inhibitor of human cytochrome P450IA2 with an IC50 of 0.07 μM. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.07 μM (human cytochrome P450IA2)[1] |
| In Vivo | Furafylline is a potent and selective inhibitor of human cytochrome P450IA2 with an IC50 of 0.07 μM in kinase experiment. Furafylline is a methylxanthine derivative that is introduced as a long-acting replacement for theophylline in the treatment of asthma. Administration of Furafylline is associated with an elevation in plasma levels of caffeine, due to inhibition of caffeine oxidation, a reaction catalysed by one or more hydrocarbon-inducible isoenzymes of P450. Furafylline has either very little or no effect on human monooxygenase activities catalysed by other isoenzymes of P450, including P4501ID1, P4501IC, P450IIIA[1]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 543.6±60.0 °C at 760 mmHg |
| Molecular Formula | C12H12N4O3 |
| Molecular Weight | 260.249 |
| Flash Point | 282.6±32.9 °C |
| Exact Mass | 260.090942 |
| PSA | 85.82000 |
| LogP | -0.24 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.637 |
| Storage condition | 2-8℃ |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2939590000 |
| HS Code | 2939590000 |
|---|