583840-03-3
583840-03-3 structure
- Name: Sorafenib N-Oxide
- Chemical Name: Sorafenib N-Oxide
- CAS Number: 583840-03-3
- Molecular Formula: C21H13ClD3F3N4O4
- Molecular Weight: 483.84300
- Create Date: 2017-07-21 15:14:10
- Modify Date: 2025-08-31 10:15:55
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Sorafenib N-oxide is an active metabolite of sorafenib (BAY 43-9006), an inhibitor of Raf-1, B-RAF, and receptor tyrosine kinases. Sorafenib N-oxide inhibits FLT3 that contains the internal tandem duplication mutation (FLT3-ITD) and inhibits proliferation of MV4-11 acute myeloid leukemia (AML) cells expressing FLT3-ITD. It is selective for AML cell lines containing FLT3-ITD over lines containing wild-type FLT3. Sorafenib N-oxide is also a linear-mixed inhibitor of the cytochrome P450 (CYP) isoform CYP3A4.
| Name | Sorafenib N-Oxide |
|---|---|
| Synonyms | 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-1-oxidopyridin-1-ium-2-carboxamide |
| Density | 1.455g/cm3 |
|---|---|
| Boiling Point | 591.655ºC at 760 mmHg |
| Melting Point | 220-222ºC |
| Molecular Formula | C21H13ClD3F3N4O4 |
| Molecular Weight | 483.84300 |
| Flash Point | 311.622ºC |
| Exact Mass | 483.10000 |
| PSA | 104.92000 |
| LogP | 6.12010 |
| Index of Refraction | 1.601 |
|
~55%
583840-03-3 |
| Literature: BAYER CORPORATION Patent: US2003/216446 A1, 2003 ; US 20030216446 A1 |
| Precursor 1 | |
|---|---|
| DownStream 0 | |