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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Ethynodiol diacetate
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297-76-7

297-76-7 structure

297-76-7 structure

Name: Ethynodiol diacetate
Chemical Name: ethynodiol diacetate
CAS Number: 297-76-7
Molecular Formula: C₂₄H₃₂O₄
Molecular Weight: 384.509
Catalog: API Hormone and endocrine-regulating drugs Birth control pills
Create Date: 2018-05-15 08:00:00
Modify Date: 2026-07-03 13:41:01
Ethynodiol diacetate is a steroidal progestin which is used as a hormonal contraceptive, it has relatively little or no potency as an androgen,has significant estrogenic effects.

Name	ethynodiol diacetate
Synonyms	beta-ethynodioldiacetate 4-ESTREN-17-ALPHA-ETHYNYL-3-BETA, 17-BETA-DIOL DIACETATE Ovulen 17-alpha-ethynyl-4-estrene-3-beta,17-dioldiacetate 8080 C. B Metrodiol 19-nor-17-alpha-pregn-4-en-20-yne-3-beta,17-diol,diacetate 3-beta,17-beta-Diacetoxy-19-nor-17-alpha-pregn-4-en-20-yne component of Demulon 17-alpha-ethynyl-19-norandrost-4-ene-3-beta,17-beta-dioldiacetate acetic acid [(3S,8R,9S,10R,13S,14S,17R)-17-acetyloxy-17-ethynyl-13-methyl-2,3,6,7,8,9,10,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] ester component of Luteolas 19-Norpregn-4-en-20-yne-3,17-diyl diacetate [(3S,8R,9S,10R,13S,14S,17R)-17-acetyloxy-17-ethynyl-13-methyl-2,3,6,7,8,9,10,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate component of Miniluteolas Ethynodiol 17-alpha-Ethynyl-19-norandrost-4-ene-3-beta,17-beta-diol diacetate Etynodiol 19-Nor-17-alpha-pregn-4-en-20-yne-3-beta,17-diol diacetate 17-alpha-Ethynyl-4-estrene-3-beta,17-diol diacetate Ethinodiol diacetate ethynodiolacetate Luteonorm 17-alpha-Ethynylestr-4-ene-3-beta,17-beta-diol acetate 3-beta, 17-beta-Diacetoxy-17-alpha-ethynyl-4-oestrene 19-Nor-17alpha-pregn-4-en-20-yn-3beta,17-diol diacetate MFCD00083326 3BETA,17BETA-DIACETOXY-17ALPHA-ETHYNYL-4-ESTRENE beta-Ethynodiol diacetate 3β,17β-Diacetoxy-17α-ethynyl-4-estrene component of Ovas 17alpha-ethynyl-4-estrene-3b,17b-diol-3,17-diacetate 17-alpha-ethynyl-3,17-dihydroxy-4-estrenediacetate Metrodiol diacetate 17-alpha-Ethynyl-3,17-dihydroxy-4-estrene diacetate ovulen50 17-alpha-Ethynyl-4-estrene-3-beta,17-beta-diol diacetate component of Metrulen 19-Norpregn-4-en-20-yne-3,17-diol, diacetate, (3beta,17alpha) etynodiol di(acetate) ETHYNODIOL DIACETATE 8080c.b (3-beta,17-alpha)-19-norpregn-4-en-20-yne-3,17-dioldiacetate 17-alpha-ethynyl-4-estrene-3-beta,17-beta-dioldiacetate 17-alpha-ethynylestr-4-ene-3-beta,17-beta-diolacetate 17a-Ethynyl-4-estren-3b,17-diol diacetate 17-(Acetyloxy)-17-ethynylestr-4-en-3-yl acetate ethinodioldiacetate Etynodiol acetate component of Conova 3-beta,17-beta-diacetoxy-17-alpha-ethynyl-4-oestrene Ethynodiol (diacetate) Continuin 19-Norpregn-4-en-20-yne-3,17-diol, 3,17-diacetate, (3β,17α) Estr-4-ene-3,17-diol, 17-ethynyl-, diacetate Femulen Cervicundin component of Demulen Double vinegethynodiol metrodioldiacetate 19-nor-17a-pregn-4-en-20-yne-3b,17-diol diacetate EINECS 206-044-9 (3β, 17α)-19-Norpregn-4-en-20-yne-3,17-diol diacetate (3-beta,17-alpha)-19-Norpregn-4-en-20-yne-3,17-diol diacetate Luto-metrodiol Ovulen 50

Description	Ethynodiol diacetate is a steroidal progestin which is used as a hormonal contraceptive, it has relatively little or no potency as an androgen,has significant estrogenic effects.
Related Catalog	Signaling Pathways >> Others >> Progesterone Receptor Research Areas >> Endocrinology

Density	1.1±0.1 g/cm3
Boiling Point	461.1±45.0 °C at 760 mmHg
Melting Point	128 - 131ºC
Molecular Formula	C₂₄H₃₂O₄
Molecular Weight	384.509
Flash Point	221.8±27.1 °C
Exact Mass	384.230072
PSA	52.60000
LogP	5.44
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.546

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RC8963000

CHEMICAL NAME :: 19-Nor-17-alpha-pregn-4-en-20-yne-3-beta,17-diol diacetate

CAS REGISTRY NUMBER :: 297-76-7

LAST UPDATED :: 199510

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: C24-H32-O4

MOLECULAR WEIGHT :: 384.56

WISWESSER LINE NOTATION :: L E5 B666 MUTJ E1 FOV1 F1UU1 OOV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 840 ug/kg

SEX/DURATION :: female 21 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 840 ug/kg

SEX/DURATION :: female 24 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - menstrual cycle changes or disorders

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 700 ug/kg

SEX/DURATION :: female 14 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 6 mg/kg

SEX/DURATION :: male 30 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

DOSE :: 240 mg/kg

SEX/DURATION :: male 30 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 16500 ug/kg

SEX/DURATION :: male 60 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 48 mg/kg

SEX/DURATION :: male 12 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 1400 ug/kg

SEX/DURATION :: female 14 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - ovaries, fallopian tubes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 140 mg/kg

SEX/DURATION :: female 14 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 120 ug/kg

SEX/DURATION :: female 3 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 1560 ug/kg

SEX/DURATION :: female 1-3 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 5 mg/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

TYPE OF TEST :: Mutation test systems - not otherwise specified

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Mammal - cattle Cells - not otherwise specified

DOSE/DURATION :: 10 mg/L

REFERENCE :: AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- Volume(issue)/page/year: 120,390,1974 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 21,387,1979

Symbol	GHS07, GHS08
Signal Word	Warning
Hazard Statements	H302-H312-H332-H351
Precautionary Statements	P280
Personal Protective Equipment	Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	Xn: Harmful;
Risk Phrases	R20/21/22
Safety Phrases	22-36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	RC8963000

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