297-76-7

• 常用中文名：双醋炔诺醇
• 常用英文名：Ethynodiol diacetate
• CAS号：297-76-7
• 分子式：C₂₄H₃₂O₄
• 分子量：384.509
• 相关类别： 原料药 激素及调节内分泌功能类药 避孕药
• 发布时间：2018-05-15 08:00:00
• 更新时间：2024-01-02 14:27:36
• Ethynodiol diacetate是一种甾体孕激素, 用作激素避孕药, 具有相对较少或没有雄激素效果, 而具有显著雌激素作用。

名称

• 中文名: 双醋炔诺醇
• 英文名: ethynodiol diacetate
• 英文别名: Metrodiol diacetate; Ethinodiol diacetate; Ovulen; Continuin; Metrodiol; Estr-4-ene-3,17-diol, 17-ethynyl-, diacetate; Femulen; Cervicundin; ETHYNODIOL DIACETATE; MFCD00083326; 3β,17β-Diacetoxy-17α-ethynyl-4-estrene; EINECS 206-044-9; 19-Norpregn-4-en-20-yne-3,17-diyl diacetate; 17a-Ethynyl-4-estren-3b,17-diol diacetate; [(3S,8R,9S,10R,13S,14S,17R)-17-acetyloxy-17-ethynyl-13-methyl-2,3,6,7,8,9,10,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate; Luto-metrodiol; Ovulen 50; Ethynodiol (diacetate)

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 461.1±45.0 °C at 760 mmHg
• 熔点: 128 - 131ºC
• 分子式: C₂₄H₃₂O₄
• 分子量: 384.509
• 闪点: 221.8±27.1 °C
• 精确质量: 384.230072
• PSA: 52.60000
• LogP: 5.44
• 外观性状: 固体;White to Almost white powder to crystal
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.546
• 储存条件: 室温，密封

生物活性

• 描述: Ethynodiol diacetate是一种甾体孕激素, 用作激素避孕药, 具有相对较少或没有雄激素效果, 而具有显著雌激素作用。
• 相关类别:
  信号通路 >> 其他 >> 孕激素受体
  研究领域 >> 内分泌

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : RC8963000 CHEMICAL NAME : 19-Nor-17-alpha-pregn-4-en-20-yne-3-beta,17-diol diacetate CAS REGISTRY NUMBER : 297-76-7 LAST UPDATED : 199510 DATA ITEMS CITED : 17 MOLECULAR FORMULA : C24-H32-O4 MOLECULAR WEIGHT : 384.56 WISWESSER LINE NOTATION : L E5 B666 MUTJ E1 FOV1 F1UU1 OOV1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 840 ug/kg SEX/DURATION : female 21 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - other measures of fertility TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 840 ug/kg SEX/DURATION : female 24 week(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - menstrual cycle changes or disorders TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 700 ug/kg SEX/DURATION : female 14 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - uterus, cervix, vagina TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 6 mg/kg SEX/DURATION : male 30 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Administration onto the skin DOSE : 240 mg/kg SEX/DURATION : male 30 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 16500 ug/kg SEX/DURATION : male 60 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 48 mg/kg SEX/DURATION : male 12 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 1400 ug/kg SEX/DURATION : female 14 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - ovaries, fallopian tubes TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 140 mg/kg SEX/DURATION : female 14 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - uterus, cervix, vagina TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 120 ug/kg SEX/DURATION : female 3 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - uterus, cervix, vagina TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 1560 ug/kg SEX/DURATION : female 1-3 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 5 mg/kg SEX/DURATION : female 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - other measures of fertility TYPE OF TEST : Mutation test systems - not otherwise specified MUTATION DATA TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Mammal - cattle Cells - not otherwise specified DOSE/DURATION : 10 mg/L REFERENCE : AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- Volume(issue)/page/year: 120,390,1974 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 21,387,1979

安全

• 符号: GHS07, GHS08
• 信号词: Warning
• 危害声明: H302-H312-H332-H351
• 警示性声明: P280
• 个人防护装备: Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
• 危害码 (欧洲): Xn: Harmful;
• 风险声明 (欧洲): R20/21/22
• 安全声明 (欧洲): 22-36
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3
• RTECS号: RC8963000