845273-93-0
845273-93-0 structure
- Name: Sevelamer carbonate
- Chemical Name: carbonic acid,2-(chloromethyl)oxirane,prop-2-en-1-amine
- CAS Number: 845273-93-0
- Molecular Formula: C7H14ClNO4
- Molecular Weight: 211.643
- Catalog: Organic raw materials Amino compound Acyclic monoamines, polyamines and their derivatives and salts
- Create Date: 2018-09-07 09:49:33
- Modify Date: 2024-01-02 10:24:33
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Sevelamer carbonate is an orally active and non-calcium-based phosphate binding agent and used for the hyperphosphatemia of chronic kidney disease (CKD)research. Sevelamer carbonate effectively lowers serum phosphorus levels hile having minimal effect on serum calcium or serum chloride levels in vivo. Sevelamer carbonate is considered as an improved, buffered form of sevelamer (HY-13995)[1][2].
| Name | carbonic acid,2-(chloromethyl)oxirane,prop-2-en-1-amine |
|---|---|
| Synonyms |
Sevelamer carbonate
GT 335-012 2-Propen-1-aminium hydrogen carbonate - 2-(chloromethyl)oxirane (1:1:1) UNII-9YCX42I8IU Sevelamercabonate |
| Description | Sevelamer carbonate is an orally active and non-calcium-based phosphate binding agent and used for the hyperphosphatemia of chronic kidney disease (CKD)research. Sevelamer carbonate effectively lowers serum phosphorus levels hile having minimal effect on serum calcium or serum chloride levels in vivo. Sevelamer carbonate is considered as an improved, buffered form of sevelamer (HY-13995)[1][2]. |
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| Related Catalog | |
| In Vivo | Sevelamer carbonate is an anion-exchange resin with the same polymeric structure as that of sevelamer hydrochloride, but with carbonate replacing chloride as the anion[4]. Sevelamer carbonate lowers serum phosphorus levels and calcium-phosphorus product to a similar extent as sevelamer hydrochloride. Additionally, Sevelamer carbonate is associated with significant effects on decreasing low-density lipoprotein cholesterol levels and may cause less metabolic acidosis than sevelamer hydrochloride in vivo[1]. Sevelamer carbonate (oral adminstration; 1% mixed in diet; 2-3 weeks) significantly reduces serum phosphate level in Npt2b-deficient mice. Npt2b attenuates the hyperphosphatemia in control animals and that sevelamer carbonate treatment has an additional benefit in maintaining serum phosphate in the normal range[3]. Sevelamer carbonate (oral adminstration; 1% mixed in diet; 2-3 weeks) does not alter serum phosphate levels in uremic WT mice (10.04 mg/dl , untreated versus 9.67mg/dl , binder-treated mg/dl) but further decreased serum phosphate levels in uremic Npt2b−/− mice in uremic mouse model[3]. Animal Model: WT and Npt2b−/− CKD mice model[3] Dosage: 1% mixed in diet Administration: Oral adminstration; 1% mixed in diet; 2-3 weeks Result: Attenuated chronic hyperphosphatemia in mice. |
| References |
[1]. Mary M Barna, et al.Sevelamer carbonate.Ann Pharmacother. 2010 Jan;44(1):127-34. |
| Molecular Formula | C7H14ClNO4 |
|---|---|
| Molecular Weight | 211.643 |
| Exact Mass | 211.061142 |
| PSA | 96.08000 |
| LogP | 1.67780 |