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863329-66-2

863329-66-2 structure

863329-66-2 structure

Name: PSI-6206
Chemical Name: (2'R)-2'-Deoxy-2'-fluoro-2'-methyl-uridine
CAS Number: 863329-66-2
Molecular Formula: C₁₀H₁₃FN₂O₅
Molecular Weight: 260.219
Catalog: Pharmaceutical intermediate API intermediate
Create Date: 2018-12-25 21:07:29
Modify Date: 2026-06-30 13:06:57
PSI-6206 is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase. PSI-6206 low potently inhibits HCV replicon with EC90 of >100 μM.

Name	(2'R)-2'-Deoxy-2'-fluoro-2'-methyl-uridine
Synonyms	1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione Sofosbuvir Intermediates 2 chloro-b-L-abinofuranosyl)-thymine biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-cboxylic Acid-d5 β-D-2'-deoxy-2'-α-F-2'-β-C-methyluridine fluoroguanosine C-methyluridine fluoro-b-D-abinofuranosyl)adenine fluoro-b-L-abinofuranosyl)-uracil deoxy-7-iodoadenosine biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-cboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester (2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine (Sofo C1) 2'-Deoxy-2'-fluoro-2'-methyluridine GS-331007 fluoro-b-D-abinofuranosyl)-5-ethyluracil Ro-2433 PSI-6206; RO-2433; PSI6206; RO2433 Uridine, 2'-deoxy-2'-fluoro-2'-Methyl-, (2'R) 1-((2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione RO fluoro-beta-d-abinofuranosyl)-5-ethyluracil deoxy-6-methoxyguanosine 5. (2'R)-2'-Deoxy-2'-fluoro-2'-Methyluridine (2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine fluoro-b-D-ribofuranosyl)-isoguanine 2'-deoxy-2'-fluoro-2'-methyluridine 1-[(2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyl-tetrahydrofuran-2-yl]pyrimidine-2,4-dione 2'-Deoxy-2-floro-2'Methyl-uridine fluoro-b-D-abinofuranosyl)cytosine 1-((2S,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione Uridine, 2'-deoxy-2'-fluoro-2'-Methyl-, (2'R)- PSI6206 O-4-C-Methylene-b-D-ribofuranosyl)thymine 1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione 2'-deoxy-2'-fluoro-2'-C-methyluridine deoxy-7-iodoguanosine fluoro-b-D-abinofuranosyl)guanine 2'-deoxy-2'-fluoro-2'-C-Methyluridine (N-1) 2'-Deoxy-2'-F-2'-C-methyluridine URI002 PSI 6206 int PSI6206 fluoro-b-D-abinofuranosyl)purine biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-cboxylic Acid biphenyl-4-yl)methyl]-2-ethoxy-d-benzimidazolecboxylic Acid Methyl Ester Sofosbuvir INT 1 Sofosbuvir imp-11 biphenyl-4-yl)methyl]-2-ethoxy-7-benzimidazolecboxylic Acid Methyl Ester Sofosbuvir Intermediate 4 2'-deoxy-2'-fluoro-2'-C-methyl-uridine O-trityl-b-L-abinofuranosyl)-uracil C-ethynyladenosine fluoro-b-D-abinofuranosyl)hypoxantine deoxy-O6-methylguanosine fluoro-b-D-abinofuranosyl)cytosine HCl Sofosbuvir int. N-1 fluoro-b-D-ribofuranosyl)purine fluoro-b-D-abinofuranosyl)-N2-isobutyrylguanine Sofosbuvir Nucleoside Derivative (GS-331007) (2'R)-2'-deoxy-2'-fluoro-2'-C-methyluridine fluoro-b-D-ribofuranosyl)-2-fluoroadenine

Description	PSI-6206 is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase. PSI-6206 low potently inhibits HCV replicon with EC90 of >100 μM.
Related Catalog	Signaling Pathways >> Anti-infection >> HCV Research Areas >> Infection
Target	EC90：>100 μM (HCV replicon)[1]
In Vitro	PSI-6206 (RO2433) is tested for anti-HCV activity in both a cell-based quantitative real-time RT-PCR assay and surrogate bovine viral diarrhea virus (BVDV) assays. PSI-6206 demonstrates no activity or cytoxicity in any assay[1]. The formation of the 5′-triphosphate (TP) of PSI-6130 (PSI-6130-TP) and RO2433 (RO2433-TP) increases with time and reached steady state levels at 48 h. RO2433-TP also inhibits RNA synthesis by the native HCV replicase isolated from HCV replicon cells and the recombinant HCV polymerase NS5B[2]. PSI-6206 (RO2433) is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase[3].
References	[1]. Clark JL, et al. Design, Synthesis, and Antiviral Activity of 2'-Deoxy-2'-fluoro-2'-C-methyl-cytidine, a Potent Inhibitor of Hepatitis C Virus Replication. J Med Chem. 2005 Aug 25;48(17):5504-8. [2]. Ma H, et al. Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor beta-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine (PSI-6130) and identification of a novel active 5'-triphosphate species. J Biol Chem. 2007 Oct 12;282(41):29 [3]. Wang P, et al. An efficient and diastereoselective synthesis of PSI-6130: a clinically efficacious inhibitor of HCV NS5B polymerase. J Org Chem. 2009 Sep 4;74(17):6819-24.

Density	1.6±0.1 g/cm3
Melting Point	237-238℃
Molecular Formula	C₁₀H₁₃FN₂O₅
Molecular Weight	260.219
Exact Mass	260.080841
PSA	104.55000
LogP	-0.77
Index of Refraction	1.596

Hazard Codes	Xi
HS Code	2934999090

817204-32-3 structure

817204-32-3

~%

863329-66-2 structure

863329-66-2

Literature: Journal of Medicinal Chemistry, , vol. 48, # 17 p. 5504 - 5508

Precursor 1
817204-32-3
DownStream 2
1064684-44-1 1190307-88-0

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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