Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: MYOMODULIN
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Myomodulin
Price: $Inquiry/1kg
Purity: 99.0%
Stocking Period: 1 Day
Contact: Vinnie

110570-93-9

110570-93-9 structure

110570-93-9 structure

Name: Myomodulin
Chemical Name: Myomodulin A trifluoroacetate salt
CAS Number: 110570-93-9
Molecular Formula: C₃₆H₆₇N₁₁O₈S₂
Molecular Weight: 846.11600
Catalog: Peptides
Create Date: 2017-12-27 14:20:02
Modify Date: 2024-01-22 21:02:45
Myomodulin is a neuropeptide present in molluscs, insects, and gastropods.

Name	Myomodulin A trifluoroacetate salt
Synonyms	myomodulin

Description	Myomodulin is a neuropeptide present in molluscs, insects, and gastropods.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Natural Products >> Others Peptides Research Areas >> Neurological Disease
In Vitro	Myomodulin decreases period and increases spike frequency in oscillator heart interneurons. Myomodulin enhances the hyperpolarization-activated cation current and inhibits the electrogenic Na/K pump[1]. A myomodulin peptide has been suggested to mediate the response of the giant glial cells to stimulation of the Leydig interneuron in the central nervous system of the leech Hirudo medicinalis. The peptide evokes a membrane outward current (EC50 approximately 2 μM), which neither desensitizes nor shows any sign of run-down, and elicits a K+ conductance increase of the glial cell membrane[2]. Myomodulin modulate ion channels in a wide variety of organisms including Aplysia, Lymnaea, and Pleurobranchaea. Myomodulin differentially modulates the potassium currents and reduces the amplitude of the Ca2+ current by 20%[3].
References	[1]. Tobin AE, et al. Myomodulin increases Ih and inhibits the NA/K pump to modulate bursting in leech heart interneurons. J Neurophysiol. 2005 Dec;94(6):3938-50. [2]. Britz FC, et al. Membrane responses of the leech giant glial cell to the peptide transmitter myomodulin. Peptides. 2002 Dec;23(12):2117-25. [3]. Wang Y, et al. Modulatory effects of myomodulin on the excitability and membrane currents in Retzius cells of the leech. J Neurophysiol. 1999 Jul;82(1):216-25.

Density	1.38g/cm3
Molecular Formula	C₃₆H₆₇N₁₁O₈S₂
Molecular Weight	846.11600
Exact Mass	845.46200
PSA	362.45000
LogP	2.55190
Index of Refraction	1.629
Storage condition	-20°C

Hazard Codes	N