33675-83-1

33675-83-1 structure

Name: (2H5)Acetamide
Chemical Name: N,N,2,2,2-pentadeuterioacetamide
CAS Number: 33675-83-1
Molecular Formula: C₂D₅NO
Molecular Weight: 64.098
Catalog: Research Areas Cancer
Create Date: 2018-02-12 08:00:00
Modify Date: 2024-01-13 18:02:50
Acetamide-d5 is the deuterium labeled Acetamide[1]. Acetamide is used as an intermediate in the synthesis of methylamine, thioacetamide, and insecticides, and as a plasticizer in leather, cloth and coatings. Acetamide has carcinogenicity[2][3].

Name	N,N,2,2,2-pentadeuterioacetamide
Synonyms	Acetamide-d (H)Acetamide Acetamide-d5

Description	Acetamide-d5 is the deuterium labeled Acetamide[1]. Acetamide is used as an intermediate in the synthesis of methylamine, thioacetamide, and insecticides, and as a plasticizer in leather, cloth and coatings. Acetamide has carcinogenicity[2][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Acetamide. IARC Monogr Eval Carcinog Risks Hum. 1999;71 Pt 3:1211-21. [3]. Moore MM, et, al. The food contaminant acetamide is not an in vivo clastogen, aneugen, or mutagen in rodent hematopoietic tissue. Regul Toxicol Pharmacol. 2019 Nov108:104451.