3614-69-5

3614-69-5 structure

Name: UNII:6LL60J9E0O
Chemical Name: (Z)-but-2-enedioic acid,N,N-dimethyl-2-[3-(1-pyridin-2-ylethyl)-1H-inden-2-yl]ethanamine
CAS Number: 3614-69-5
Molecular Formula: C₂₄H₂₈N₂O₄
Molecular Weight: 408.490
Catalog: API Antiallergic Antihistamine
Create Date: 2018-08-08 17:05:51
Modify Date: 2024-01-05 14:18:11
Dimethindene maleate is a selective histamine H1 antagonist with antihistamine effects. Dimethindene maleate can be used for the research of hypersensitivity reactions[1][2][3].

Name	(Z)-but-2-enedioic acid,N,N-dimethyl-2-[3-(1-pyridin-2-ylethyl)-1H-inden-2-yl]ethanamine
Synonyms	Fenistil-retard N,N-Dimethyl-2-{3-[1-(2-pyridinyl)ethyl]-1H-inden-2-yl}ethanamine (2Z)-2-butenedioate (1:1) Fenistil Forthistal maleate 1H-Indene-2-ethanamine, N,N-dimethyl-3-[1-(2-pyridinyl)ethyl]-, (2Z)-2-butenedioate (1:1) Dimethinden maleate Forhistal maleate Dimethpyrindene maleate Dimethindene maleate Dimetindene maleate UNII:6LL60J9E0O SU-6518 3-[a-(2'-Pyridyl)ethyl]-2-(b-dimethylaminoethyl)indene Maleate (1:1) N,N-Dimethyl-2-{3-[1-(pyridin-2-yl)ethyl]-1H-inden-2-yl}ethanamine (2Z)-but-2-enedioate (1:1) dimetindene hydrogen maleate

Description	Dimethindene maleate is a selective histamine H1 antagonist with antihistamine effects. Dimethindene maleate can be used for the research of hypersensitivity reactions[1][2][3].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
Target	Human Endogenous Metabolite
In Vitro	Dimethindene maleate (1-1000 μM) suppresses the cromakalim-induced/glibenclamide-sensitive K＋ currents in a concentration-dependent and reversible manner with an IC50 value of 29.5 μM[2]. Dimethindene maleate (1-1000 μM) inhibits Y-26763-induced glibenclamide-sensitive K＋ currents with an IC50 value of 49 μM[2].
In Vivo	Dimethindene maleate (0.25 mg; i.p. once) affects wound healing in mice[1]. Animal Model: C57BL/6 mice with wound healing[1] Dosage: 0.25 mg Administration: Intraperitoneal injection; 0.25 mg once Result: Significantly delayed skin wound and only showed wound closure impairment in the initial phase wound healing.

Boiling Point	416.3ºC at 760mmHg
Melting Point	159-161℃
Molecular Formula	C₂₄H₂₈N₂O₄
Molecular Weight	408.490
Flash Point	205.6ºC
Exact Mass	408.204895
PSA	90.73000
LogP	3.85850
Water Solubility	Slightly soluble in water, soluble in methanol

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 3,534,1961

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 3,534,1961

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 3,534,1961

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 3,534,1961

Hazard Codes	Xn
HS Code	2933399090

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%