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3614-69-5

3614-69-5 structure
3614-69-5 structure
  • Name: UNII:6LL60J9E0O
  • Chemical Name: (Z)-but-2-enedioic acid,N,N-dimethyl-2-[3-(1-pyridin-2-ylethyl)-1H-inden-2-yl]ethanamine
  • CAS Number: 3614-69-5
  • Molecular Formula: C24H28N2O4
  • Molecular Weight: 408.490
  • Catalog: API Antiallergic Antihistamine
  • Create Date: 2018-08-08 17:05:51
  • Modify Date: 2024-01-05 14:18:11
  • Dimethindene maleate is a selective histamine H1 antagonist with antihistamine effects. Dimethindene maleate can be used for the research of hypersensitivity reactions[1][2][3].

Name (Z)-but-2-enedioic acid,N,N-dimethyl-2-[3-(1-pyridin-2-ylethyl)-1H-inden-2-yl]ethanamine
Synonyms Fenistil-retard
N,N-Dimethyl-2-{3-[1-(2-pyridinyl)ethyl]-1H-inden-2-yl}ethanamine (2Z)-2-butenedioate (1:1)
Fenistil
Forthistal maleate
1H-Indene-2-ethanamine, N,N-dimethyl-3-[1-(2-pyridinyl)ethyl]-, (2Z)-2-butenedioate (1:1)
Dimethinden maleate
Forhistal maleate
Dimethpyrindene maleate
Dimethindene maleate
Dimetindene maleate
UNII:6LL60J9E0O
SU-6518
3-[a-(2'-Pyridyl)ethyl]-2-(b-dimethylaminoethyl)indene Maleate (1:1)
N,N-Dimethyl-2-{3-[1-(pyridin-2-yl)ethyl]-1H-inden-2-yl}ethanamine (2Z)-but-2-enedioate (1:1)
dimetindene hydrogen maleate
Description Dimethindene maleate is a selective histamine H1 antagonist with antihistamine effects. Dimethindene maleate can be used for the research of hypersensitivity reactions[1][2][3].
Related Catalog
Target

Human Endogenous Metabolite

In Vitro Dimethindene maleate (1-1000 μM) suppresses the cromakalim-induced/glibenclamide-sensitive K+ currents in a concentration-dependent and reversible manner with an IC50 value of 29.5 μM[2]. Dimethindene maleate (1-1000 μM) inhibits Y-26763-induced glibenclamide-sensitive K+ currents with an IC50 value of 49 μM[2].
In Vivo Dimethindene maleate (0.25 mg; i.p. once) affects wound healing in mice[1]. Animal Model: C57BL/6 mice with wound healing[1] Dosage: 0.25 mg Administration: Intraperitoneal injection; 0.25 mg once Result: Significantly delayed skin wound and only showed wound closure impairment in the initial phase wound healing.
Boiling Point 416.3ºC at 760mmHg
Melting Point 159-161℃
Molecular Formula C24H28N2O4
Molecular Weight 408.490
Flash Point 205.6ºC
Exact Mass 408.204895
PSA 90.73000
LogP 3.85850
Water Solubility Slightly soluble in water, soluble in methanol

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UT0830000
CAS REGISTRY NUMBER :
3614-69-5
LAST UPDATED :
199106
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C20-H24-N2.C4-H4-O4
MOLECULAR WEIGHT :
408.54
WISWESSER LINE NOTATION :
L56 BHJ C2N1&1 DY1&- BT6NJ &QV2VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
618 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 3,534,1961
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
26800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 3,534,1961
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 3,534,1961
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
888 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 3,534,1961
Hazard Codes Xn
HS Code 2933399090
HS Code 2933399090
Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%