Name | (Z)-but-2-enedioic acid,N,N-dimethyl-2-[3-(1-pyridin-2-ylethyl)-1H-inden-2-yl]ethanamine |
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Synonyms |
Fenistil-retard
N,N-Dimethyl-2-{3-[1-(2-pyridinyl)ethyl]-1H-inden-2-yl}ethanamine (2Z)-2-butenedioate (1:1) Fenistil Forthistal maleate 1H-Indene-2-ethanamine, N,N-dimethyl-3-[1-(2-pyridinyl)ethyl]-, (2Z)-2-butenedioate (1:1) Dimethinden maleate Forhistal maleate Dimethpyrindene maleate Dimethindene maleate Dimetindene maleate UNII:6LL60J9E0O SU-6518 3-[a-(2'-Pyridyl)ethyl]-2-(b-dimethylaminoethyl)indene Maleate (1:1) N,N-Dimethyl-2-{3-[1-(pyridin-2-yl)ethyl]-1H-inden-2-yl}ethanamine (2Z)-but-2-enedioate (1:1) dimetindene hydrogen maleate |
Description | Dimethindene maleate is a selective histamine H1 antagonist with antihistamine effects. Dimethindene maleate can be used for the research of hypersensitivity reactions[1][2][3]. |
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Related Catalog | |
Target |
Human Endogenous Metabolite |
In Vitro | Dimethindene maleate (1-1000 μM) suppresses the cromakalim-induced/glibenclamide-sensitive K+ currents in a concentration-dependent and reversible manner with an IC50 value of 29.5 μM[2]. Dimethindene maleate (1-1000 μM) inhibits Y-26763-induced glibenclamide-sensitive K+ currents with an IC50 value of 49 μM[2]. |
In Vivo | Dimethindene maleate (0.25 mg; i.p. once) affects wound healing in mice[1]. Animal Model: C57BL/6 mice with wound healing[1] Dosage: 0.25 mg Administration: Intraperitoneal injection; 0.25 mg once Result: Significantly delayed skin wound and only showed wound closure impairment in the initial phase wound healing. |
Boiling Point | 416.3ºC at 760mmHg |
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Melting Point | 159-161℃ |
Molecular Formula | C24H28N2O4 |
Molecular Weight | 408.490 |
Flash Point | 205.6ºC |
Exact Mass | 408.204895 |
PSA | 90.73000 |
LogP | 3.85850 |
Water Solubility | Slightly soluble in water, soluble in methanol |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Hazard Codes | Xn |
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HS Code | 2933399090 |
HS Code | 2933399090 |
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Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |