1180-35-4

1180-35-4 structure

Name: Acetylepipodophyllotoxin
Chemical Name: (5S,5aR,8aR,9R)-8-Oxo-9-(3,4,5-trimethoxyphenyl)-5,5a,6,8,8a,9-he xahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl acetate
CAS Number: 1180-35-4
Molecular Formula: C₂₄H₂₄O₉
Molecular Weight: 456.44
Catalog: Natural product Lignans
Create Date: 2016-10-09 09:20:32
Modify Date: 2024-01-01 22:24:23
Epipodophyllotoxin acetate (4-O-Epipodophyllotoxinyl acetate; compound 4) is a cyclolignan that exhibits antineoplastic and antiviral activities. Epipodophyllotoxin acetate inhibits HSV and VSV, with IC50s of 0.2 and 0.1 μg/mL, respectively[1].

Name	(5S,5aR,8aR,9R)-8-Oxo-9-(3,4,5-trimethoxyphenyl)-5,5a,6,8,8a,9-he xahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl acetate
Synonyms	ethynyl-magnesium bromide Ethynylmagnesium bromide solution O-Acetyl-epipodophyllotoxin Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 9-(acetyloxy)-5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)-, (5R,5aR,8aR,9S)- acetylepipodophyllotoxin ethynyl-MgBr (5S,5aR,8aR,9R)-8-Oxo-9-(3,4,5-trimethoxyphenyl)-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl acetate acetylenemagnesium bromide acetylenyl magnesium bromide bromomagnesium acetylide epipodophyllotoxin acetate

Description	Epipodophyllotoxin acetate (4-O-Epipodophyllotoxinyl acetate; compound 4) is a cyclolignan that exhibits antineoplastic and antiviral activities. Epipodophyllotoxin acetate inhibits HSV and VSV, with IC50s of 0.2 and 0.1 μg/mL, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Anti-infection >> HSV Research Areas >> Infection
References	[1]. Feliciano AS, et, al. Antineoplastic and antiviral activities of some cyclolignans. Planta Med. 1993 Jun;59(3):246-9.

Hazard Codes	Xi

108-24-7

4375-07-9

1180-35-4

Literature: Hartwell; Schrecker Journal of the American Chemical Society, 1951 , vol. 73, p. 2909,2916

Precursor 2
108-24-7 4375-07-9
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