Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Scrophulein
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Huang

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Scrophulein
Price: ￥4480.0/5mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Liu jia

ShangHai DC Chemicals Co.,Ltd
China
Product Name: Cirsimaritin
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Lai

DC Chemicals Limited
China
Product Name: Cirsimaritin
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: CIRSIMARITIN
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

6601-62-3

6601-62-3 structure

6601-62-3 structure

Name: Scrophulein
Chemical Name: cirsimaritin
CAS Number: 6601-62-3
Molecular Formula: C₁₇H₁₄O₆
Molecular Weight: 314.289
Catalog: Natural product Flavonoids
Create Date: 2018-05-31 08:00:00
Modify Date: 2024-01-02 12:26:43
Cirsimaritin binds weakly to the benzodiazepine site on GABAA receptors, with antidepressant, anxiolytic and antinociceptive activities.

Name	cirsimaritin
Synonyms	5,4'-dihydroxy-6,7-dimethoxyflavone 5-hydroxy-2-(4-hydroxyphenyl)-6,7-dimethoxychromen-4-one Flavone, 4',5-dihydroxy-6,7-dimethoxy- 6,7-Dimethoxyscutellarein Circimaritin 7-Methylcapillarisin 5-Hydroxy-2-(4-hydroxyphenyl)-6,7-dimethoxy-4H-chromen-4-one cirsimartin 5-hydroxy-2-(4-hydroxyphenyl)-6,7-dimethoxy-chromen-4-one Scrophulein 4H-1-Benzopyran-4-one,5-hydroxy-2-(4-hydroxyphenyl)-6,7-dimethoxy Skrofulein 4H-1-Benzopyran-4-one, 5-hydroxy-2-(4-hydroxyphenyl)-6,7-dimethoxy- 4',5-Dihydroxy-6,7-dimethoxyflavone cirsimaritin

Description	Cirsimaritin binds weakly to the benzodiazepine site on GABAA receptors, with antidepressant, anxiolytic and antinociceptive activities.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor Research Areas >> Neurological Disease Natural Products >> Others
In Vivo	Cirsimaritin significantly reduces the anxiety in mice. Cirsimaritin does not decrease by co-administration of flumazenil (2.5 mg/kg) with salvigenin, rosmanol and cirsimaritin (10 mg/kg), indicating that the high-affinity benzodiazepine binding site is not involved in the anxiolytic activity induced by these compounds[1].
References	[1]. Abdelhalim A, et al. Antidepressant, Anxiolytic and Antinociceptive Activities of Constituents from Rosmarinus Officinalis. J Pharm Pharm Sci. 2015;18(4):448-59.

Density	1.4±0.1 g/cm3
Boiling Point	563.6±50.0 °C at 760 mmHg
Molecular Formula	C₁₇H₁₄O₆
Molecular Weight	314.289
Flash Point	211.5±23.6 °C
Exact Mass	314.079041
PSA	89.13000
LogP	1.97
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.646
Storage condition	?20°C

Symbol	GHS06, GHS09
Signal Word	Danger
Hazard Statements	H301-H410
Precautionary Statements	P273-P301 + P310-P501
Hazard Codes	T,N
Risk Phrases	25-50
Safety Phrases	45-61
RIDADR	UN 2811 6.1 / PGIII
HS Code	2914509090

Precursor 6
117951-82-3 1486-50-6 642-71-7 22248-14-2
1486-51-7 17742-46-0
DownStream 0

HS Code	2914509090
Summary	HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%