1311423-89-8

1311423-89-8 structure

Name: YF-2
Chemical Name: N-[4-Chloro-3-(trifluoromethyl)phenyl]-2-[2-(dimethylamino)ethoxy ]-6-ethoxybenzamide
CAS Number: 1311423-89-8
Molecular Formula: C₂₀H₂₂ClF₃N₂O₃
Molecular Weight: 430.84800
Catalog: Signaling Pathways Epigenetics Histone Acetyltransferase
Create Date: 2017-01-31 05:27:12
Modify Date: 2024-01-16 18:12:41
YF-2 is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC50s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease[1].

Name	N-[4-Chloro-3-(trifluoromethyl)phenyl]-2-[2-(dimethylamino)ethoxy ]-6-ethoxybenzamide
Synonyms	N-[4-chloro-2-(propan-2-yloxy)phenyl]-2,2-dimethylpropanamide N-[4-chloro-3-(trifluoromethyl)phenyl]-2-[2-(dimethylamino)ethoxy]-6-ethoxybenzamide Propanamide,N-[4-chloro-2-(1-methylethoxy)phenyl]-2,2-dimethyl

Description	YF-2 is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC50s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Acetyltransferase Research Areas >> Neurological Disease
Target	CBP:2.75 μM (EC50) PCAF:29.04 μM (EC50) GCN5:49.31 μM (EC50)
In Vitro	YF-2 (0.03, 0.1, 0.25, 0.5, 1, 2.5, 5, 15, 40 and 80 μM, 72 hours) inhibits the preliferation of U251, CCRF-CEM, Hs578T, NCI-ADR-RES cells[1].
In Vivo	YF-2 (20 mg/kg, 2 hours befor electric shock or 5 mg/kg, 30 min before the electric shock, i.p.) rescues the defect in contextual memory in mice, and shows no effect on contextual memory alone at 20 mg/kg in mice[1].
References	[1]. FENG, Yen, et al. HISTONE ACETYLTRANSFERASE ACTIVATORS AND USES THEREOF. WO 2011072243A1.