66592-89-0
66592-89-0 structure
- Name: Kevetrin (hydrochloride)
- Chemical Name: 3-cyanopropyl carbamimidothioate,hydrochloride
- CAS Number: 66592-89-0
- Molecular Formula: C5H10ClN3S
- Molecular Weight: 179.67100
- Catalog: Signaling Pathways Apoptosis MDM-2/p53
- Create Date: 2018-09-23 21:04:54
- Modify Date: 2024-01-10 18:51:29
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Kevetrin hydrochloride is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity. Target：p53in vitro: Kevetrin activates p53 which in turn induces the expressions of p21 and PUMA (p53 up-regulated modulator of apoptosis), thereby inhibiting cancer cell growth and causing tumor cell apoptosis. Kevetrin may be effective in drug-resistant cancers with mutated p53. p53 tumor suppressor, a transcription factor regulating the expression of many stress response genes and mediating various anti-proliferative processes, is often mutated in cancer cells. in vivo: Kevetrin has demonstrated potent anti-tumor efficacy against various carcinoma xenograft models: lung, breast, colon, prostate and squamous cell carcinoma, and in a leukemia tumor model. In drug-resistant cell lines, Kevetrin has shown excellent activity, galvanizing the Company to focus on Kevetrin's development potential in this area.
| Name | 3-cyanopropyl carbamimidothioate,hydrochloride |
|---|---|
| Synonyms |
Carbamimidothioic acid,3-cyanopropyl ester,hydrochloride(1:1)
UNII-NL6L2371DP S-(3-cyano-propyl)-isothiourea,hydrochloride KEVETRIN Carbamimidothioic acid,3-cyanopropyl ester,monohydrochloride S-(3-Cyan-propyl)-isothioharnstoff,Hydrochlorid Kevetrin hydrochloride 4-Isothioureidobutyronitrile hydrochloride CarbaMiMidothioic acid, 3-cyanopropyl ester, hydrochloride (1:1) Kevetrin HCl Kevetrin (hydrochloride) |
| Description | Kevetrin hydrochloride is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity. Target：p53in vitro: Kevetrin activates p53 which in turn induces the expressions of p21 and PUMA (p53 up-regulated modulator of apoptosis), thereby inhibiting cancer cell growth and causing tumor cell apoptosis. Kevetrin may be effective in drug-resistant cancers with mutated p53. p53 tumor suppressor, a transcription factor regulating the expression of many stress response genes and mediating various anti-proliferative processes, is often mutated in cancer cells. in vivo: Kevetrin has demonstrated potent anti-tumor efficacy against various carcinoma xenograft models: lung, breast, colon, prostate and squamous cell carcinoma, and in a leukemia tumor model. In drug-resistant cell lines, Kevetrin has shown excellent activity, galvanizing the Company to focus on Kevetrin's development potential in this area. |
|---|---|
| Related Catalog |
| Melting Point | 125-127 ºC |
|---|---|
| Molecular Formula | C5H10ClN3S |
| Molecular Weight | 179.67100 |
| Exact Mass | 179.02800 |
| PSA | 98.96000 |
| LogP | 2.51888 |
| Appearance | white solid |
| Storage condition | -20℃ |
|
~63%
66592-89-0 |
| Literature: CELLCEUTIX CORPORATION; MENON, Krishna Patent: WO2010/135170 A2, 2010 ; Location in patent: Page/Page column 20-21 ; |
| Precursor 1 | |
|---|---|
| DownStream 0 | |