Kevetrin (hydrochloride)
Modify Date: 2024-01-10 18:51:29
Kevetrin (hydrochloride) structure
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Common Name | Kevetrin (hydrochloride) | ||
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| CAS Number | 66592-89-0 | Molecular Weight | 179.67100 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C5H10ClN3S | Melting Point | 125-127 ºC | |
| MSDS | N/A | Flash Point | N/A | |
Use of Kevetrin (hydrochloride)Kevetrin hydrochloride is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity. Target：p53in vitro: Kevetrin activates p53 which in turn induces the expressions of p21 and PUMA (p53 up-regulated modulator of apoptosis), thereby inhibiting cancer cell growth and causing tumor cell apoptosis. Kevetrin may be effective in drug-resistant cancers with mutated p53. p53 tumor suppressor, a transcription factor regulating the expression of many stress response genes and mediating various anti-proliferative processes, is often mutated in cancer cells. in vivo: Kevetrin has demonstrated potent anti-tumor efficacy against various carcinoma xenograft models: lung, breast, colon, prostate and squamous cell carcinoma, and in a leukemia tumor model. In drug-resistant cell lines, Kevetrin has shown excellent activity, galvanizing the Company to focus on Kevetrin's development potential in this area. |
| Name | 3-cyanopropyl carbamimidothioate,hydrochloride |
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| Synonym | More Synonyms |
| Description | Kevetrin hydrochloride is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity. Target：p53in vitro: Kevetrin activates p53 which in turn induces the expressions of p21 and PUMA (p53 up-regulated modulator of apoptosis), thereby inhibiting cancer cell growth and causing tumor cell apoptosis. Kevetrin may be effective in drug-resistant cancers with mutated p53. p53 tumor suppressor, a transcription factor regulating the expression of many stress response genes and mediating various anti-proliferative processes, is often mutated in cancer cells. in vivo: Kevetrin has demonstrated potent anti-tumor efficacy against various carcinoma xenograft models: lung, breast, colon, prostate and squamous cell carcinoma, and in a leukemia tumor model. In drug-resistant cell lines, Kevetrin has shown excellent activity, galvanizing the Company to focus on Kevetrin's development potential in this area. |
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| Related Catalog |
| Melting Point | 125-127 ºC |
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| Molecular Formula | C5H10ClN3S |
| Molecular Weight | 179.67100 |
| Exact Mass | 179.02800 |
| PSA | 98.96000 |
| LogP | 2.51888 |
| Appearance of Characters | white solid |
| Storage condition | -20℃ |
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~63%
Kevetrin (hydro... CAS#:66592-89-0 |
| Literature: CELLCEUTIX CORPORATION; MENON, Krishna Patent: WO2010/135170 A2, 2010 ; Location in patent: Page/Page column 20-21 ; |
| Precursor 1 | |
|---|---|
| DownStream 0 | |
| Carbamimidothioic acid,3-cyanopropyl ester,hydrochloride(1:1) |
| UNII-NL6L2371DP |
| S-(3-cyano-propyl)-isothiourea,hydrochloride |
| KEVETRIN |
| Carbamimidothioic acid,3-cyanopropyl ester,monohydrochloride |
| S-(3-Cyan-propyl)-isothioharnstoff,Hydrochlorid |
| Kevetrin hydrochloride |
| 4-Isothioureidobutyronitrile hydrochloride |
| CarbaMiMidothioic acid, 3-cyanopropyl ester, hydrochloride (1:1) |
| Kevetrin HCl |
| Kevetrin (hydrochloride) |