930800-38-7

930800-38-7 structure

Name: IA-Alkyne
Chemical Name: N-(5-Hexyn-1-yl)-2-iodoacetamide
CAS Number: 930800-38-7
Molecular Formula: C₈H₁₂INO
Molecular Weight: 265.09100
Catalog: Signaling Pathways Membrane Transporter/Ion Channel TRP Channel
Create Date: 2016-01-22 01:53:25
Modify Date: 2024-01-11 20:26:52
IA-Alkyne (Iodoacetamide-alkyne; N-Hex-5-ynyl-2-iodo-acetamide) is a TRP channel (TRPC) agonist and has the potential for the study of respiratory infection[1]. IA-Alkyne can be used to develop an isotopically tagged probe for quantitative cysteine-reactivity profiling[2].

Name	N-(5-Hexyn-1-yl)-2-iodoacetamide
Synonyms	MFCD18839149

Description	IA-Alkyne (Iodoacetamide-alkyne; N-Hex-5-ynyl-2-iodo-acetamide) is a TRP channel (TRPC) agonist and has the potential for the study of respiratory infection[1]. IA-Alkyne can be used to develop an isotopically tagged probe for quantitative cysteine-reactivity profiling[2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Infection Research Areas >> Inflammation/Immunology
Target	IC50: TRPC[1]
In Vitro	IA-alkyne (2.5-10 μM; 1 hour) can react with cysteines. Soluble fractions of HeLa cell lysates (2.0 mg/ml) are treated with IA-alkyne. Labeled proteome samples are conjugated with a fluorescent rhodamine-azide tag through CuAAC, and analyzed by SDS-PAGE. In-gel fluorescence imaging reveals that IA-alkyne has a strong fluorescent intensity[2].
References	[1]. David L. Use of trp channel agonists to treat infections. Patent US20130203715A1. [2]. Zorin NA, et al. Inhibition by iodoacetamide and acetylene of the H-D-exchange reaction catalyzed by Thiocapsa roseopersicina hydrogenase. Eur J Biochem. 1996 Oct 15;241(2):675-81.

Hazard Codes	T+