137813-35-5

137813-35-5 structure

Name: Cyclo [Arg-Gly-Asp-D-Phe-Val]
Chemical Name: cyclo(arg-gly-asp-d-phe-val)
CAS Number: 137813-35-5
Molecular Formula: C₂₆H₃₈N₈O₇
Molecular Weight: 574.62900
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2019-01-07 20:00:14
Modify Date: 2026-06-30 20:56:06
Cyclo(Arg-Gly-Asp-D-Phe-Val) is an integrin αvβ3 inhibitor. Cyclo(Arg-Gly-Asp-D-Phe-Val) has antitumor activity. Cyclo(Arg-Gly-Asp-D-Phe-Val) can be used for the research of acute myeloid leukemia[1].

Name	cyclo(arg-gly-asp-d-phe-val)
Synonyms	Cyclog-Gls-Asp-D-Phe-Val) CYCLOG-GLY-ASP-D-PHE-VAL) Cyclo(L-ginylglycyl-L-α-asptyl-D-phenylalanyl-L-valyl) EMD 66203, c(RGDfV) cyclo(RGD-DPhe-V) RGDFV PTIDE, CYCLIC Cyclog-Gly-Asp-D-Phe-Val) - - Calbiochem CYCLO(RGDD-FV) RGDFV PEPTIDE,CYCLIC cRGDfV Cyclo(-g-Gly-Asp-D-Phe-Val) trifluoroacetate salt Cyclo(Arg-Gly-Asp-D-Phe-Val)

Description	Cyclo(Arg-Gly-Asp-D-Phe-Val) is an integrin αvβ3 inhibitor. Cyclo(Arg-Gly-Asp-D-Phe-Val) has antitumor activity. Cyclo(Arg-Gly-Asp-D-Phe-Val) can be used for the research of acute myeloid leukemia[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cytoskeleton >> Integrin
Target	αvβ3[1]
In Vitro	Cyclo(Arg-Gly-Asp-d-Phe-Val) (c(RGDfV)) (35 nM, 4-24 h) disruptes the adhesion and migration between the tumor cells and the matrix, induces the leukemia cells to leave the protective microenvironment and increases their sensitivity to cell cycle-dependent agents[1]. Cell Cycle Analysis[1] Cell Line: MV4–11 cells Concentration: 35 nM Incubation Time: 24 h Result: Affected the leukemia cell cycle, decreased the G0/G1 phase of leukemia cells in the 3D and 2D culture systems and increased the S phase of leukemia cells in the 3D and 2D culture systems. Apoptosis Analysis[1] Cell Line: MV4–11 cells Concentration: 35 nM Incubation Time: 24 h Result: Increased the apoptosis rates.