Cyclo [Arg-Gly-Asp-D-Phe-Val]

Modify Date: 2024-01-06 13:54:41

Cyclo [Arg-Gly-Asp-D-Phe-Val] Structure
Cyclo [Arg-Gly-Asp-D-Phe-Val] structure
Common Name Cyclo [Arg-Gly-Asp-D-Phe-Val]
CAS Number 137813-35-5 Molecular Weight 574.62900
Density N/A Boiling Point N/A
Molecular Formula C26H38N8O7 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Cyclo [Arg-Gly-Asp-D-Phe-Val]


Cyclo(Arg-Gly-Asp-D-Phe-Val) is an integrin αvβ3 inhibitor. Cyclo(Arg-Gly-Asp-D-Phe-Val) has antitumor activity. Cyclo(Arg-Gly-Asp-D-Phe-Val) can be used for the research of acute myeloid leukemia[1].

 Names

Name cyclo(arg-gly-asp-d-phe-val)
Synonym More Synonyms

 Cyclo [Arg-Gly-Asp-D-Phe-Val] Biological Activity

Description Cyclo(Arg-Gly-Asp-D-Phe-Val) is an integrin αvβ3 inhibitor. Cyclo(Arg-Gly-Asp-D-Phe-Val) has antitumor activity. Cyclo(Arg-Gly-Asp-D-Phe-Val) can be used for the research of acute myeloid leukemia[1].
Related Catalog
Target

αvβ3[1]

In Vitro Cyclo(Arg-Gly-Asp-d-Phe-Val) (c(RGDfV)) (35 nM, 4-24 h) disruptes the adhesion and migration between the tumor cells and the matrix, induces the leukemia cells to leave the protective microenvironment and increases their sensitivity to cell cycle-dependent agents[1]. Cell Cycle Analysis[1] Cell Line: MV4–11 cells Concentration: 35 nM Incubation Time: 24 h Result: Affected the leukemia cell cycle, decreased the G0/G1 phase of leukemia cells in the 3D and 2D culture systems and increased the S phase of leukemia cells in the 3D and 2D culture systems. Apoptosis Analysis[1] Cell Line: MV4–11 cells Concentration: 35 nM Incubation Time: 24 h Result: Increased the apoptosis rates.

 Chemical & Physical Properties

Molecular Formula C26H38N8O7
Molecular Weight 574.62900
Exact Mass 574.28600
PSA 244.70000
LogP 0.52700

 Synonyms

RGDFV PEPTIDE,CYCLIC
Cyclo(Arg-Gly-Asp-D-Phe-Val)