61370-87-4

61370-87-4 structure

Name: TYR-D-ALA-GLY-PHE-MET
Chemical Name: (2S)-2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoic acid
CAS Number: 61370-87-4
Molecular Formula: C₂₈H₃₇N₅O₇S
Molecular Weight: 587.68800
Catalog: Signaling Pathways GPCR/G Protein Opioid Receptor
Create Date: 2019-09-07 13:12:55
Modify Date: 2024-02-02 11:15:37
[D-Ala2]-Met-Enkephalin, an opioid peptide, is a potent opioid agonist. [D-Ala2]-Met-Enkephalin inhibits ACh-induced and suckling-induced oxytocin (OT) release[1][2].

Name	(2S)-2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoic acid
Synonyms	2-Ala-met-enkephalin Dalmee DAMET

Description	[D-Ala2]-Met-Enkephalin, an opioid peptide, is a potent opioid agonist. [D-Ala2]-Met-Enkephalin inhibits ACh-induced and suckling-induced oxytocin (OT) release[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Neurological Disease
In Vivo	[D-Ala2]-Met-Enkephalin (0.01-1μg; ICV; once) inhibits suckling-induced oxytocin (OT) release in lactating mice[1]. Animal Model: Lactating rats[1] Dosage: 0.01, 0.1 and 1 μg Administration: Intracerebroventrical injection Result: Inhibited ACh-induced and suckling-induced OT release.
References	[1]. Haldar J, et, al. Morphine, β-endorphin and [D-Ala2] Met-enkephalin inhibit oxytocin release by acetylcholine and suckling. 1982 Jul–Aug;3(4):663-8. [2]. Godoy AM, et, al. Modulation of the escape response by [d-Ala2]Met-enkephalin in the crab Chasmagnathus. 1995 Mar;50(3):445-51.