140678-12-2

140678-12-2 structure

Name: u-Conotoxin GIIIB
Chemical Name: μ-CONOTOXIN GIIIB
CAS Number: 140678-12-2
Molecular Formula: C₁₀₁H₁₇₅N₃₉O₃₀S₇
Molecular Weight: 2640.17
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Sodium Channel
Create Date: 2016-11-27 12:41:58
Modify Date: 2026-07-07 11:51:37
μ-Conotoxin GIIIB is a 22-residue polypeptide that can be isolated from the venom of piscivorous cone snail Conus geographus. μ-Conotoxin GIIIB is a NaV1.4 channel inhibitor. μ-Conotoxin GIIIB blocks muscle cell's contraction[1][2][3].

Name	μ-CONOTOXIN GIIIB
Synonyms	M-CONOTOXIN GIIIB RDCCT(Hyp)(Hyp)RKC KDRRCK(Hyp)MKCCA-NH2 ARG-ASP-CYS-CYS-THR-HYP-HYP-ARG-LYS-CYS-LYS-ASP-ARG-GLN-CYS-LYS-HYP-GLN-ARG-CYS-CYS-ALA-NH2 GEOGRAPHUTOXIN II u-Conotoxin GIIIB\| MU-CONOTOXIN GIIIB mhu-conotoxin GIIIB μ-Conotoxin GIIIB Geoaphutoxin II (GTXII) GEOAPHUTOXIN II U-conotoxin giiib H-g-Asp-Cys-Cys-Thr-Hyp-Hyp-g-Lys-Cys-Lys-Asp-g-g-Cys-Lys-Hyp-Met-Lys-Cys-Cys-Ala-NH2 (Disulfide bonds between Cys3 and Cys15/Cys4 and Cys20/ Cys10 and Cys21) g-Asp-Cys-Cys-Thr-Hyp-Hyp-g-Lys-Cys-Lys-Asp-g-g-Cys-Lys-Hyp-Met-Lys-Cys-Cys-Ala-NH2 [Disulfide bridges undefined] Conotoxin GIIIB MU-CONOTOXIN GIIIB L-Alaninamide, L-ginyl-L-α-asptyl-L-cysteinyl-L-cysteinyl-L-threonyl-(4R)-4-hydroxy-L-prolyl-(4R)-4-hydroxy-L-prolyl-L-ginyl-L-lysyl-L-cysteinyl-L-lysyl-L-α-asptyl-L-ginyl-L-ginyl-L-cysteinyl-L-lysyl-(4R)-4-hydroxy-L-prolyl-L-methionyl-L-lysyl-L-cysteinyl-L-cysteinyl-, cyclic (3→15),(4→2 μ-Conotoxin GIIIB H-g-Asp-Cys-Cys-Thr-Hyp-Hyp-g-Lys-Cys-Lys-Asp-g-g-Cys-Lys-Hyp-Met-Lys-Cys-Cys-Ala-NH2 (Disulfide bonds between Cys3 and Cys15/Cys4 and Cys20/Cys10 and Cys21) Conotoxin GIIIB H-G-ASP-CYS-CYS-THR-HYP-HYP-G-LYS-CYS-LYS-ASP-G-G-CYS-LYS-HYP-MET-LYS-CYS-CYS-ALA-NH2 GTXII G-ASP-CYS-CYS-THR-HYP-HYP-G-LYS-CYS-LYS-ASP-G-G-CYS-LYS-HYP-MET-LYS-CYS-CYS-ALA-NH2 GEOAPHUTOXIN II (GTXII) G-ASP-CYS-CYS-THR-HYP-HYP-G-LYS-CYS-LYS-ASP-G-GLN-CYS-LYS-HYP-GLN-G-CYS-CYS-ALA-NH2 Μ-CONOTOXIN GIIIB

Description	μ-Conotoxin GIIIB is a 22-residue polypeptide that can be isolated from the venom of piscivorous cone snail Conus geographus. μ-Conotoxin GIIIB is a NaV1.4 channel inhibitor. μ-Conotoxin GIIIB blocks muscle cell's contraction[1][2][3].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease
Target	NaV1.4 Channel[2]
References	[1]. orres NS. Activation of reverse Na+-Ca2+ exchanger by skeletal Na+ channel isoform increases excitation-contraction coupling efficiency in rabbit cardiomyocytes. Am J Physiol Heart Circ Physiol. 2021 Feb 1;320(2):H593-H603. [2]. Garcia N, et al. Involvement of the Voltage-Gated Calcium Channels L- P/Q- and N-Types in Synapse Elimination During Neuromuscular Junction Development. Mol Neurobiol. 2022 Jul;59(7):4044-4064. [3]. Hill JM, et al. Three-dimensional solution structure of mu-conotoxin GIIIB, a specific blocker of skeletal muscle sodium channels. Biochemistry. 1996 Jul 9;35(27):8824-35.