140678-12-2

• 常用中文名：芋螺毒素U-CONOTOXIN GIIIB
• 常用英文名：u-Conotoxin GIIIB
• CAS号：140678-12-2
• 分子式：C₁₀₁H₁₇₅N₃₉O₃₀S₇
• 分子量：2640.17
• 相关类别： 信号通路 跨膜转运 钠通道
• 发布时间：2016-11-27 12:41:58
• 更新时间：2026-07-07 11:51:37
• μ-锥虫毒素GIIIB是从地理锥螺的毒液中分离得到的一种22个残基的多肽。μ-芋螺毒素GIIIB是一种NaV1.4通道抑制剂。μ-芋螺毒素GIIIB阻断肌肉细胞收缩[1][2][3]。

名称

• 中文名: 芋螺毒素U-CONOTOXIN GIIIB
• 英文名: μ-CONOTOXIN GIIIB
• 中文别名: M-芋螺毒素GIIIB
• 英文别名: M-CONOTOXIN GIIIB; RDCCT(Hyp)(Hyp)RKC KDRRCK(Hyp)MKCCA-NH2; ARG-ASP-CYS-CYS-THR-HYP-HYP-ARG-LYS-CYS-LYS-ASP-ARG-GLN-CYS-LYS-HYP-GLN-ARG-CYS-CYS-ALA-NH2; GEOGRAPHUTOXIN II; u-Conotoxin GIIIB| MU-CONOTOXIN GIIIB; mhu-conotoxin GIIIB; μ-Conotoxin GIIIB Geoaphutoxin II (GTXII); GEOAPHUTOXIN II; U-conotoxin giiib; H-g-Asp-Cys-Cys-Thr-Hyp-Hyp-g-Lys-Cys-Lys-Asp-g-g-Cys-Lys-Hyp-Met-Lys-Cys-Cys-Ala-NH2 (Disulfide bonds between Cys3 and Cys15/Cys4 and Cys20/ Cys10 and Cys21); g-Asp-Cys-Cys-Thr-Hyp-Hyp-g-Lys-Cys-Lys-Asp-g-g-Cys-Lys-Hyp-Met-Lys-Cys-Cys-Ala-NH2 [Disulfide bridges undefined]; Conotoxin GIIIB; MU-CONOTOXIN GIIIB; L-Alaninamide, L-ginyl-L-α-asptyl-L-cysteinyl-L-cysteinyl-L-threonyl-(4R)-4-hydroxy-L-prolyl-(4R)-4-hydroxy-L-prolyl-L-ginyl-L-lysyl-L-cysteinyl-L-lysyl-L-α-asptyl-L-ginyl-L-ginyl-L-cysteinyl-L-lysyl-(4R)-4-hydroxy-L-prolyl-L-methionyl-L-lysyl-L-cysteinyl-L-cysteinyl-, cyclic (3→15),(4→2; μ-Conotoxin GIIIB H-g-Asp-Cys-Cys-Thr-Hyp-Hyp-g-Lys-Cys-Lys-Asp-g-g-Cys-Lys-Hyp-Met-Lys-Cys-Cys-Ala-NH2 (Disulfide bonds between Cys3 and Cys15/Cys4 and Cys20/Cys10 and Cys21); Conotoxin GIIIB; H-G-ASP-CYS-CYS-THR-HYP-HYP-G-LYS-CYS-LYS-ASP-G-G-CYS-LYS-HYP-MET-LYS-CYS-CYS-ALA-NH2; GTXII; G-ASP-CYS-CYS-THR-HYP-HYP-G-LYS-CYS-LYS-ASP-G-G-CYS-LYS-HYP-MET-LYS-CYS-CYS-ALA-NH2; GEOAPHUTOXIN II (GTXII); G-ASP-CYS-CYS-THR-HYP-HYP-G-LYS-CYS-LYS-ASP-G-GLN-CYS-LYS-HYP-GLN-G-CYS-CYS-ALA-NH2; Μ-CONOTOXIN GIIIB

物化性质

• 分子式: C₁₀₁H₁₇₅N₃₉O₃₀S₇
• 分子量: 2640.17
• 精确质量: 2638.14000
• PSA: 1338.14000
• 外观性状: 冻干的粉末

生物活性

• 描述: μ-锥虫毒素GIIIB是从地理锥螺的毒液中分离得到的一种22个残基的多肽。μ-芋螺毒素GIIIB是一种NaV1.4通道抑制剂。μ-芋螺毒素GIIIB阻断肌肉细胞收缩[1][2][3]。
• 相关类别:
  信号通路 >> 跨膜转运 >> 钠通道
  研究领域 >> 神经疾病
• 靶点:

  NaV1.4 Channel[2]

• 参考文献:

  [1]. orres NS. Activation of reverse Na+-Ca2+ exchanger by skeletal Na+ channel isoform increases excitation-contraction coupling efficiency in rabbit cardiomyocytes. Am J Physiol Heart Circ Physiol. 2021 Feb 1;320(2):H593-H603.

  [2]. Garcia N, et al. Involvement of the Voltage-Gated Calcium Channels L- P/Q- and N-Types in Synapse Elimination During Neuromuscular Junction Development. Mol Neurobiol. 2022 Jul;59(7):4044-4064.

  [3]. Hill JM, et al. Three-dimensional solution structure of mu-conotoxin GIIIB, a specific blocker of skeletal muscle sodium channels. Biochemistry. 1996 Jul 9;35(27):8824-35.

安全

• 安全声明 (欧洲): 22-24/25
• 危险品运输编码: UN 3462 6
• 包装等级: III
• 危险类别: 6.1(b)