481629-87-2

481629-87-2 structure

Name: PAZ-417
Chemical Name: 2-[1-[(4-tert-butylphenyl)methyl]-5-(3-methylphenyl)indol-3-yl]-2-oxoacetic acid
CAS Number: 481629-87-2
Molecular Formula: C₂₈H₂₇NO₃
Molecular Weight: 425.51900
Catalog: Signaling Pathways Metabolic Enzyme/Protease PAI-1
Create Date: 2017-02-07 05:55:15
Modify Date: 2026-07-06 12:11:33
Aleplasinin is an orally active, potent, BBB-penetrated and selectiveSERPINE1 (PAI-1, Plasminogen activator inhibitor-1) inhibitor. Aleplasinin increases amyloid-β (Aβ) catabolism and ameliorates amyloid-related pathology. Aleplasinin improves memory deficiency. Aleplasinin can be used for Alzheimer's disease research[1][2].

Name	2-[1-[(4-tert-butylphenyl)methyl]-5-(3-methylphenyl)indol-3-yl]-2-oxoacetic acid
Synonyms	2-{1-[(4-tert-butylphenyl)methyl]-5-(3-methylphenyl)-1H-indol-3-yl}-2-oxoacetic acid Allasinin (1-(4-(1,1-Dimethylethyl)benzyl)-5-(3-methylphenyl)-1H-indol-3-yl)oxoacetic acid 2-(1-(4-(tert-butyl)benzyl)-5-(m-tolyl)-1H-indol-3-yl)-2-oxoaceticacid Plasminogen activator inhibitor-1,PAI-1,Serpin family,Abeta,inhibit,Inhibitor,Amyloid-β,Alzheimer's disease,BBB-penetrated,β-amyloid ptide,orally active,Allasinin,memory deficiency 1H-Indole-3-acetic acid, 1-[[4-(1,1-dimethylethyl)phenyl]methyl]-5-(3-methylphenyl)-α-oxo UNII-LL56J87F3X Allasinin, 10 mM in DMSO Aleplasinin

Description	Aleplasinin is an orally active, potent, BBB-penetrated and selectiveSERPINE1 (PAI-1, Plasminogen activator inhibitor-1) inhibitor. Aleplasinin increases amyloid-β (Aβ) catabolism and ameliorates amyloid-related pathology. Aleplasinin improves memory deficiency. Aleplasinin can be used for Alzheimer's disease research[1][2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> PAI-1 Research Areas >> Neurological Disease
References	[1]. Zhao J, Pei G. Evoking plasmin for beta-amyloid clearance. Cell Res. 2008 Aug;18(8):803-4. [2]. Kellici TF, Pilka ES, Bodkin MJ. Therapeutic Potential of Targeting Plasminogen Activator Inhibitor-1 in COVID-19. Trends Pharmacol Sci. 2021 Jun;42(6):431-433.

79-37-8

481630-84-6

~95%

481629-87-2

Literature: Wyeth Patent: US2003/125371 A1, 2003 ;

Precursor 1
79-37-8
DownStream 0