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481631-45-2

481631-45-2 structure
481631-45-2 structure
  • Name: Diaplasinin
  • Chemical Name: 1-benzyl-3-pentyl-2-[6-(2H-tetrazol-5-ylmethoxy)naphthalen-2-yl]indole
  • CAS Number: 481631-45-2
  • Molecular Formula: C32H31N5O
  • Molecular Weight: 501.62100
  • Catalog: Signaling Pathways Metabolic Enzyme/Protease PAI-1
  • Create Date: 2017-04-05 19:09:02
  • Modify Date: 2025-08-27 13:55:36
  • Diaplasinin (PAI-749) is a plasminogen activator inhibitor-1 (PAI-1) inhibitor with IC50 of 295 nm. Antithrombotic efficacy[1].

Name 1-benzyl-3-pentyl-2-[6-(2H-tetrazol-5-ylmethoxy)naphthalen-2-yl]indole
Synonyms PAI-749
UNII-NRL66AVH63
Diaplasinin
Description Diaplasinin (PAI-749) is a plasminogen activator inhibitor-1 (PAI-1) inhibitor with IC50 of 295 nm. Antithrombotic efficacy[1].
Related Catalog
In Vitro PAI-749 is a potent and selective synthetic antagonist of plasminogen activator inhibitor 1 (PAI-1) that preserved tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA) activities in the presence of PAI-1 (IC50 values, 157 and 87 nM, respectively)[2]. PAI-749 quenches the fluorescence (Fl) of fluorophore-tagged PAI-1 (PAI-NBD119) with the apparent Kd of 254 nM) and the IC50 of 140 nM[2].
References

[1]. A J Lucking, et al. Effect of the small molecule plasminogen activator inhibitor-1 (PAI-1) inhibitor, PAI-749, in clinical models of fibrinolysis. J Thromb Haemost. 2010 Jun;8(6):1333-9.

[2]. Stephen J Gardell, et al. Neutralization of plasminogen activator inhibitor I (PAI-1) by the synthetic antagonist PAI-749 via a dual mechanism of action. Mol Pharmacol. 2007 Oct;72(4):897-906.

Density 1.21g/cm3
Boiling Point 759.2ºC at 760mmHg
Molecular Formula C32H31N5O
Molecular Weight 501.62100
Flash Point 413ºC
Exact Mass 501.25300
PSA 68.62000
LogP 7.33460
Index of Refraction 1.661
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