612847-42-4

612847-42-4 structure

Name: Merck-22-6
Chemical Name: N-[2-(diethylamino)ethyl]-3-[4-[[4-(2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]methyl]phenyl]-2-phenylquinoxaline-6-carboxamide
CAS Number: 612847-42-4
Molecular Formula: C₄₀H₄₃N₇O₂
Molecular Weight: 653.81500
Catalog: Signaling Pathways Apoptosis Caspase
Create Date: 2016-06-30 20:02:05
Modify Date: 2024-01-08 17:28:02
Akt1/Akt2-IN-2 (compound 7) is an allosteric dual Akt1 and Akt2 inhibitor (IC50=138 nM and 212 nM, respectively). Akt1/Akt2-IN-2 increases activity of caspase-3, and inhibits viability of a number of tumor cells[1].

Name	N-[2-(diethylamino)ethyl]-3-[4-[[4-(2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]methyl]phenyl]-2-phenylquinoxaline-6-carboxamide

Description	Akt1/Akt2-IN-2 (compound 7) is an allosteric dual Akt1 and Akt2 inhibitor (IC50=138 nM and 212 nM, respectively). Akt1/Akt2-IN-2 increases activity of caspase-3, and inhibits viability of a number of tumor cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Apoptosis >> Caspase Signaling Pathways >> PI3K/Akt/mTOR >> Akt
Target	Akt1:138 nM (IC50) Akt2:212 nM (IC50) Akt3:7.2 mM (IC50) Caspase-3
In Vitro	Akt1/Akt2-IN-2 (compound 7) 对 LnCaP，HT29，MCF7，A2780 细胞有细胞毒性[1]。 Akt1/Akt2-IN-2 (2 μM, 4 μM) 分别在2 μM和4 μM时，诱导 LnCaP 细胞中 caspase-3 的活性增加 3 倍或 6.6 倍[1]。
References	[1]. Zhao Z, et al. Development of potent, allosteric dual Akt1 and Akt2 inhibitors with improved physical properties and cell activity. Bioorg Med Chem Lett. 2008 Jan 1;18(1):49-53.

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612847-42-4

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